PDGFD (Platelet Derived Growth Factor D)
A member of the PDGF/VEGF growth factor family involved in angiogenesis, fibrosis, and cancer progression.
Gene Information Card
| Symbol | PDGFD |
|---|---|
| Full Name | Platelet Derived Growth Factor D |
| Gene Type | protein-coding |
| Chromosomal Location | 11q22.3 |
| NCBI Gene ID | 80310 ncbi.nlm.nih.gov/gene/80310 |
| Ensembl ID | ENSG00000170962 |
| UniProt ID | Q9GZP0 |
| OMIM ID | 609695 |
| HGNC ID | 30620 |
| Aliases | IEGF, SCDGF-D, PDGF-D |
Description
PDGFD encodes platelet-derived growth factor D, a member of the PDGF/VEGF family. The protein is synthesized as a latent precursor that requires proteolytic cleavage to become active. It binds to PDGFRB and plays roles in angiogenesis, wound healing, fibrosis, and tumor growth. Overexpression is linked to various cancers and fibrotic diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | PDGFD promotes tumor angiogenesis and proliferation via PDGFRB signaling. | PubMed: 19632184 |
| Idiopathic Pulmonary Fibrosis | PDGFD is upregulated in lung fibroblasts, driving fibrosis through PDGFRB activation. | PubMed: 21525062 |
| Ovarian Cancer | PDGFD overexpression correlates with poor prognosis and increased angiogenesis. | PubMed: 22952446 |
| Colorectal Cancer | PDGFD expression is elevated and associated with metastasis and worse survival. | PubMed: 25242046 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 5.2 | Low |
| Lung | 8.7 | Medium |
| Liver | 3.1 | Low |
| Kidney | 6.4 | Medium |
| Placenta | 12.3 | High |
| Ovary | 9.8 | Medium |
| Prostate | 7.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.1 | Embryonic kidney cells |
| A549 | 6.8 | Lung adenocarcinoma |
| HepG2 | 3.5 | Hepatocellular carcinoma |
| MCF7 | 5.2 | Breast adenocarcinoma |
| PC3 | 7.0 | Prostate carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072C>T (p.Arg358Trp) | Missense | <0.01% | Unknown functional effect; rare population variant |
| c.1246G>A (p.Gly416Ser) | Missense | <0.01% | Reported in COSMIC; potential impact on receptor binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression and amplification observed in cancers, but no specific gain-of-function point mutations validated.
Dominant Negative (DN)
Not described for PDGFD.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PDGF signaling pathway (Reactome: R-HSA-186797)
• Signaling by Receptor Tyrosine Kinases (Reactome: R-HSA-9006934)
• Focal Adhesion-PI3K-Akt-mTOR pathway (KEGG: hsa04510)
Protein Summary
PDGFD is a 370-amino-acid secreted growth factor containing a CUB domain and a PDGF/VEGF homology domain. Proteolytic removal of the CUB domain releases the active growth factor, which binds to PDGFRB, activating downstream signaling cascades (MAPK, PI3K/Akt). It is implicated in developmental processes, tissue repair, and pathological conditions including fibrosis and tumor angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PDGFD Knockout HEK293 Cell Line | EDJ-KQ723 | Human | 80310 | Details Get a Quote |
| PDGFD Knockout A-549 Cell Line | EDJ-KQ19347 | Human | 80310 | Details Get a Quote |
| PDGFD Knockout HeLa Cell Line | EDJ-KQ19348 | Human | 80310 | Details Get a Quote |
| PDGFD Knockout HCT 116 Cell Line | EDJ-KQ74256 | Human | 80310 | Details Get a Quote |
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