PDGFC (Platelet Derived Growth Factor C)
A member of the PDGF family involved in cell growth, angiogenesis, and tissue repair, with implications in cancer and fibrosis.
Gene Information Card
| Symbol | PDGFC |
|---|---|
| Full Name | Platelet Derived Growth Factor C |
| Gene Type | protein-coding |
| Chromosomal Location | 4q32.1 |
| NCBI Gene ID | 56034 ncbi.nlm.nih.gov/gene/56034 |
| Ensembl ID | ENSG00000138678 |
| UniProt ID | Q9NRA1 |
| OMIM ID | 608452 |
| HGNC ID | 8801 |
| Aliases | PDGF-C, SCDGF, VEGF-E |
Description
PDGFC encodes platelet-derived growth factor C, a member of the PDGF family. The protein is a ligand for PDGF receptors (PDGFRA and PDGFRB) and plays a key role in cell proliferation, migration, angiogenesis, and wound healing. It is synthesized as a latent precursor requiring proteolytic activation. Dysregulation of PDGFC is implicated in various cancers, fibrotic diseases, and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression or amplification of PDGFC promotes tumor growth and angiogenesis via autocrine/paracrine PDGFR signaling. | COSMIC; PMID: 19029981 |
| Idiopathic Pulmonary Fibrosis | Increased PDGFC expression in lung fibroblasts drives fibrosis through PDGFRA activation. | PMID: 21532029 |
| Systemic Sclerosis | PDGFC contributes to dermal fibrosis via enhanced fibroblast proliferation and collagen deposition. | PMID: 22158541 |
| Glioma | PDGFC overexpression correlates with tumor grade and poor prognosis, activating PDGFRA signaling. | PMID: 15696212 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 5.2 | Low |
| Lung | 8.7 | Medium |
| Liver | 3.1 | Low |
| Kidney | 6.4 | Medium |
| Placenta | 12.3 | High |
| Skeletal Muscle | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Embryonic kidney cells; moderate expression |
| A549 | 7.1 | Lung carcinoma; elevated expression |
| HepG2 | 3.2 | Hepatocellular carcinoma; low expression |
| MCF7 | 6.8 | Breast cancer; moderate expression |
| U87MG | 9.3 | Glioblastoma; high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.125G>A (p.Arg42His) | Missense | <0.01% | Unknown functional impact; rare variant |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Reported in COSMIC; potential loss of function |
| Amplification | Copy number gain | Variable | Observed in glioblastoma and other cancers; gain of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg163Trp) may impair ligand-receptor binding or activation.
Gain of Function (GOF)
Gene amplification or overexpression leads to increased PDGFR signaling, promoting tumorigenesis.
Dominant Negative (DN)
Not reported for PDGFC.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PDGF signaling pathway (Reactome: R-HSA-186797)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• RAS signaling pathway (KEGG: hsa04014)
• Focal adhesion (KEGG: hsa04510)
Protein Summary
PDGFC is a secreted growth factor composed of a CUB domain and a PDGF/VEGF homology domain. It is proteolytically cleaved to release the active growth factor domain, which binds to PDGFRA and PDGFRB receptors, activating downstream signaling cascades (e.g., MAPK, PI3K/Akt). The protein is involved in embryonic development, wound healing, and angiogenesis. Aberrant PDGFC signaling is linked to fibrosis and tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PDGFC Knockout HEK293 Cell Line | EDJ-KQ1199 | Human | 56034 | Details Get a Quote |
| PDGFC Knockout A-549 Cell Line | EDJ-KQ20504 | Human | 56034 | Details Get a Quote |
| PDGFC Knockout HCT 116 Cell Line | EDJ-KQ20505 | Human | 56034 | Details Get a Quote |
| PDGFC Knockout HeLa Cell Line | EDJ-KQ20506 | Human | 56034 | Details Get a Quote |
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