PDCL2: Phosducin-Like 2 Gene
A member of the phosducin-like protein family involved in G-protein signaling regulation
Gene Information Card
| Symbol | PDCL2 |
|---|---|
| Full Name | Phosducin-Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 9q34.13 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000106991 |
| UniProt ID | Q9Y2B0 |
| OMIM ID | 604425 |
| HGNC ID | 8771 |
| Aliases | PhLP2, Phosducin-like protein 2 |
Description
PDCL2 (Phosducin-Like 2) is a protein-coding gene that encodes a member of the phosducin-like protein family. The encoded protein is involved in the regulation of G-protein signaling by binding to G-protein beta-gamma subunits and modulating their activity. PDCL2 is expressed in various tissues and may play a role in cellular signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Detectable |
| K562 | 7.5 | Low expression |
| A549 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.01% | Unknown effect |
| c.456G>A | Synonymous | <0.01% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported
Gain of Function (GOF)
No confirmed gain-of-function mutations reported
Dominant Negative (DN)
No confirmed dominant-negative mutations reported
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • signal transduction (GO:0007165) |
| • G-protein beta-subunit binding (GO:0031683) |
Pathways
• G-protein signaling pathway (Reactome: R-HSA-388396)
Protein Summary
The PDCL2 protein (UniProt Q9Y2B0) is a 25 kDa phosducin-like protein that contains a thioredoxin-like fold. It interacts with G-protein beta-gamma subunits and may modulate their availability or activity in signal transduction. The protein is predominantly cytoplasmic and is expressed in multiple tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PDCL2 Knockout HEK293 Cell Line | EDJ-KQ8538 | Human | 132954 | Details Get a Quote |
| PDCL2 Knockout HeLa Cell Line | EDJ-KQ58323 | Human | 132954 | Details Get a Quote |
| PDCL2 Knockout A-549 Cell Line | EDJ-KQ66811 | Human | 132954 | Details Get a Quote |
| PDCL2 Knockout HCT 116 Cell Line | EDJ-KQ75213 | Human | 132954 | Details Get a Quote |
