PDCD2L (Programmed Cell Death 2 Like)
A gene encoding a protein with potential roles in apoptosis and cell cycle regulation, related to PDCD2.
Gene Information Card
| Symbol | PDCD2L |
|---|---|
| Full Name | Programmed Cell Death 2 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 84306 ncbi.nlm.nih.gov/gene/84306 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q9BRP8 |
| OMIM ID | 617470 |
| HGNC ID | 30021 |
| Aliases | FLJ20699, MGC13170 |
Description
PDCD2L (Programmed Cell Death 2 Like) is a protein-coding gene located on chromosome 19q13.2. The encoded protein shares sequence similarity with PDCD2, a protein implicated in apoptosis. PDCD2L may play a role in cell cycle regulation and programmed cell death, though its exact functions are still under investigation. Expression data suggest broad tissue distribution.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Brain | 8.1 | Low |
| Liver | 6.4 | Low |
| Heart | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Embryonic kidney |
| HeLa | 12.8 | Cervical carcinoma |
| K562 | 10.1 | Leukemia |
| HepG2 | 7.5 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No recurrent mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • protein binding |
| • nucleus | • cytoplasm |
Pathways
• No specific pathways curated
Protein Summary
The PDCD2L protein (UniProt Q9BRP8) is 344 amino acids long and contains a conserved domain similar to PDCD2. It is predicted to localize to the nucleus and cytoplasm. Its exact molecular function remains unclear, but it may be involved in regulating cell death and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PDCD2L Knockout HEK293 Cell Line | EDJ-KQ51836 | Human | 84306 | Details Get a Quote |
| PDCD2L Knockout HeLa Cell Line | EDJ-KQ57578 | Human | 84306 | Details Get a Quote |
| PDCD2L Knockout A-549 Cell Line | EDJ-KQ66074 | Human | 84306 | Details Get a Quote |
| PDCD2L Knockout HCT 116 Cell Line | EDJ-KQ74496 | Human | 84306 | Details Get a Quote |
