PCYOX1L Gene - Prenylcysteine Oxidase 1 Like
Comprehensive genetic and functional information for PCYOX1L
Gene Information Card
| Symbol | PCYOX1L |
|---|---|
| Full Name | prenylcysteine oxidase 1 like |
| Gene Type | gene with protein product |
| Chromosomal Location | 5q32 |
| NCBI Gene ID | 78991 ncbi.nlm.nih.gov/gene/78991 |
| Ensembl ID | ENSG00000145882 |
| UniProt ID | Q8NBM8 |
| OMIM ID | 621338 |
| HGNC ID | HGNC:28477 |
| Aliases | MGC3265 |
Description
PCYOX1L (prenylcysteine oxidase 1 like) is a protein-coding gene located on chromosome 5q32. It is predicted to be involved in the catabolism of prenylated proteins, specifically the oxidative cleavage of prenylcysteine residues. The protein is localized to peroxisomes and may play a role in cellular detoxification processes. The gene is expressed in various tissues, with highest expression in the liver and kidney.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Medium |
| Testis | 5.2 | Low |
| Lung | 4.1 | Low |
| Brain | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| A549 | 8.9 | Lung carcinoma cell line |
| HEK293 | 6.7 | Embryonic kidney cells |
| MCF7 | 3.4 | Breast adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Gly41=) | Synonymous | Not reported | No known effect |
| c.456A>G (p.Thr152Ala) | Missense | Not reported | Unknown |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been characterized.
Gain of Function (GOF)
No gain-of-function mutations have been described.
Dominant Negative (DN)
No dominant-negative effects reported.
View complete mutation data：
Gene Ontology (GO)
| • prenylcysteine oxidase activity | • FAD binding |
| • peroxisome | • oxidation-reduction process |
Pathways
• Prenylated protein catabolism
• Peroxisomal lipid metabolism
Protein Summary
The PCYOX1L protein is a predicted prenylcysteine oxidase that localizes to peroxisomes. It contains a conserved FAD-binding domain and is likely involved in the oxidative cleavage of prenylated proteins, contributing to cellular homeostasis. The protein is expressed in multiple tissues, with higher levels in metabolic organs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PCYOX1L Knockout HEK293 Cell Line | EDJ-KQ14712 | Human | 78991 | Details Get a Quote |
| PCYOX1L Knockout A-549 Cell Line | EDJ-KQ45034 | Human | 78991 | Details Get a Quote |
| PCYOX1L Knockout HCT 116 Cell Line | EDJ-KQ45035 | Human | 78991 | Details Get a Quote |
| PCYOX1L Knockout HeLa Cell Line | EDJ-KQ45036 | Human | 78991 | Details Get a Quote |
