PCYOX1
Prenylcysteine Oxidase 1
Gene Information Card
| Symbol | PCYOX1 |
|---|---|
| Full Name | prenylcysteine oxidase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p13.3 |
| NCBI Gene ID | 51449 ncbi.nlm.nih.gov/gene/51449 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9UHG3 |
| OMIM ID | 610676 |
| HGNC ID | 17690 |
| Aliases | PCL1, farnesylcysteine lyase |
Description
PCYOX1 encodes prenylcysteine oxidase 1, an enzyme that catalyzes the oxidation of prenylcysteine derivatives (e.g., farnesylcysteine and geranylgeranylcysteine) to produce hydrogen peroxide and the corresponding prenyl aldehyde. This reaction is involved in the degradation of prenylated proteins and regulation of oxidative stress. The gene is expressed in multiple tissues and has been implicated in cancer, cardiovascular disease, and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered PCYOX1 expression may affect prenylated protein turnover and oxidative stress, influencing tumor progression. | COSMIC; literature |
| Cardiovascular disease | PCYOX1-mediated hydrogen peroxide production may contribute to oxidative damage in vascular tissues. | Literature |
| Metabolic syndrome | Potential role in lipid metabolism and insulin resistance via prenylcysteine processing. | Literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.1 | Low |
| Brain | 6.3 | Low |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Liver cancer cell line |
| HEK293 | 9.8 | Embryonic kidney cells |
| A549 | 7.2 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | missense | 0.01% (gnomAD) | Unknown functional impact |
| c.457G>A (p.Gly153Ser) | missense | 0.005% (gnomAD) | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may reduce enzymatic activity, impairing prenylcysteine clearance.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • prenylcysteine oxidase activity | • FAD binding |
| • oxidation-reduction process | • hydrogen peroxide metabolic process |
| • protein prenylation |
Pathways
• Prenylated protein catabolism
• Reactive oxygen species metabolism
Protein Summary
Prenylcysteine oxidase 1 is a 506-amino acid FAD-dependent enzyme localized to peroxisomes. It catalyzes the oxidative cleavage of prenylcysteine thioethers, producing hydrogen peroxide and prenyl aldehydes. The enzyme plays a key role in the degradation of farnesylated and geranylgeranylated proteins, regulating cellular levels of prenylated signaling molecules and contributing to redox homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PCYOX1 Knockout HEK293 Cell Line | EDJ-KQ11099 | Human | 51449 | Details Get a Quote |
| PCYOX1L Knockout HEK293 Cell Line | EDJ-KQ14712 | Human | 78991 | Details Get a Quote |
| PCYOX1 Knockout A-549 Cell Line | EDJ-KQ39053 | Human | 51449 | Details Get a Quote |
| PCYOX1 Knockout HCT 116 Cell Line | EDJ-KQ39054 | Human | 51449 | Details Get a Quote |
| PCYOX1 Knockout HeLa Cell Line | EDJ-KQ39055 | Human | 51449 | Details Get a Quote |
| PCYOX1L Knockout A-549 Cell Line | EDJ-KQ45034 | Human | 78991 | Details Get a Quote |
| PCYOX1L Knockout HCT 116 Cell Line | EDJ-KQ45035 | Human | 78991 | Details Get a Quote |
| PCYOX1L Knockout HeLa Cell Line | EDJ-KQ45036 | Human | 78991 | Details Get a Quote |
