PCBP4: Poly(rC) Binding Protein 4
A member of the KH-domain containing RNA-binding protein family involved in mRNA stability and translational regulation.
Gene Information Card
| Symbol | PCBP4 |
|---|---|
| Full Name | Poly(rC) Binding Protein 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.2 |
| NCBI Gene ID | 57060 ncbi.nlm.nih.gov/gene/57060 |
| Ensembl ID | ENSG00000163947 |
| UniProt ID | P57723 |
| OMIM ID | 611679 |
| HGNC ID | 8749 |
| Aliases | MCG10, LIP4, CBP, HNRPE4, hnRNP-E4 |
Description
PCBP4 (poly(rC) binding protein 4) encodes a member of the KH-domain containing RNA-binding protein family. The protein binds to poly(rC) sequences and is involved in regulation of mRNA stability, translational silencing, and may function as a tumor suppressor. It is located on chromosome 3p21.2, a region frequently deleted in lung and breast cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of heterozygosity at 3p21.2; reduced PCBP4 expression correlates with tumor progression | PMID: 11719458 |
| Breast cancer | Decreased expression in tumor tissues; potential tumor suppressor role | PMID: 14559847 |
| Prostate cancer | Downregulation of PCBP4 associated with aggressive disease | PMID: 17934463 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Prostate | 9.1 | Low |
| Testis | 15.2 | Medium |
| Brain | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung adenocarcinoma) | 10.1 | Moderate expression |
| MCF7 (breast cancer) | 7.4 | Low expression |
| PC3 (prostate cancer) | 8.9 | Low expression |
| HEK293 (embryonic kidney) | 14.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; likely loss of function |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Substitution in KH domain; may affect RNA binding |
| c.487_489del (p.Lys163del) | Deletion | <0.01% | In-frame deletion; impact unknown |
Mutation functional classification
Loss of Function (LOF)
Mutations affecting the start codon or KH domain likely result in loss of RNA binding and tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • poly(U) RNA binding (GO:0008266) |
| • mRNA 3'-UTR binding (GO:0003730) | • regulation of translation (GO:0006417) |
| • negative regulation of cell proliferation (GO:0008285) |
Pathways
• mRNA surveillance pathway (KEGG: hsa03015)
• RNA transport (KEGG: hsa03013)
Protein Summary
PCBP4 is a 366-amino acid protein containing three KH domains. It binds specifically to poly(rC) sequences in RNA and is involved in post-transcriptional regulation, including mRNA stabilization and translational repression. The protein is predominantly nuclear but can shuttle to the cytoplasm. It is considered a candidate tumor suppressor due to its location in a common deletion region and its downregulation in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PCBP4 Knockout HEK293 Cell Line | EDJ-KQ14697 | Human | 57060 | Details Get a Quote |
| PCBP4 Knockout A-549 Cell Line | EDJ-KQ45003 | Human | 57060 | Details Get a Quote |
| PCBP4 Knockout HCT 116 Cell Line | EDJ-KQ45004 | Human | 57060 | Details Get a Quote |
| PCBP4 Knockout HeLa Cell Line | EDJ-KQ45005 | Human | 57060 | Details Get a Quote |
