PARVG Gene - Parvin Gamma
Comprehensive genomic and proteomic analysis of PARVG, a member of the parvin family involved in cell adhesion and cytoskeletal organization.
Gene Information Card
| Symbol | PARVG |
|---|---|
| Full Name | Parvin Gamma |
| Gene Type | Protein coding |
| Chromosomal Location | 22q13.31 |
| NCBI Gene ID | 64098 ncbi.nlm.nih.gov/gene/64098 |
| Ensembl ID | ENSG00000100298 |
| UniProt ID | Q9HBI0 |
| OMIM ID | 608121 |
| HGNC ID | 14653 |
| Aliases | FLJ20186, MGC117188, parvin-3 |
Description
PARVG (parvin gamma) is a protein-coding gene that encodes a member of the parvin family of actin-binding proteins. Parvins are involved in cell adhesion, cytoskeletal organization, and integrin signaling. PARVG localizes to focal adhesions and plays a role in cell migration and survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect cell adhesion and migration | COSMIC, literature |
| Immunodeficiency | Potential role in immune cell adhesion | OMIM, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Lung | 6.3 | Low |
| Kidney | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.3 | Leukemia cell line |
| HEK 293 | 7.8 | Embryonic kidney |
| HeLa | 5.2 | Cervical cancer |
| A549 | 4.6 | Lung cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.01% | Unknown |
| c.456G>A | Synonymous | <0.01% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • focal adhesion (GO:0005925) |
| • cell adhesion (GO:0007155) | • actin cytoskeleton organization (GO:0030036) |
Pathways
• Integrin signaling pathway
• Focal adhesion pathway
Protein Summary
Parvin gamma is a 42 kDa actin-binding protein that localizes to focal adhesions. It interacts with integrin-linked kinase (ILK) and other cytoskeletal proteins to regulate cell adhesion, spreading, and migration. The protein contains two calponin homology (CH) domains that mediate actin binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARVG Knockout HEK293 Cell Line | EDJ-KQ14688 | Human | 64098 | Details Get a Quote |
| PARVG Knockout HeLa Cell Line | EDJ-KQ57024 | Human | 64098 | Details Get a Quote |
| PARVG Knockout A-549 Cell Line | EDJ-KQ65530 | Human | 64098 | Details Get a Quote |
| PARVG Knockout HCT 116 Cell Line | EDJ-KQ73965 | Human | 64098 | Details Get a Quote |
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