PARVA (Parvin Alpha)
Actin-binding protein involved in cell adhesion, migration, and signaling
Gene Information Card
| Symbol | PARVA |
|---|---|
| Full Name | Parvin Alpha |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.3 |
| NCBI Gene ID | 55742 ncbi.nlm.nih.gov/gene/55742 |
| Ensembl ID | ENSG00000197771 |
| UniProt ID | Q9NVD7 |
| OMIM ID | 608120 |
| HGNC ID | 14652 |
| Aliases | CH-ILKBP, actopaxin, FLJ10159 |
Description
PARVA encodes parvin alpha, a member of the parvin family of actin-binding proteins. Parvin alpha localizes to focal adhesions and interacts with integrin-linked kinase (ILK) and other cytoskeletal proteins to regulate cell adhesion, spreading, and migration. It plays a role in signal transduction pathways influencing cell survival and proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression of PARVA affects focal adhesion dynamics and cell migration, contributing to tumor invasion and metastasis. | PubMed studies; COSMIC |
| Cardiovascular disease | PARVA is involved in vascular smooth muscle cell adhesion and migration, potentially influencing atherosclerosis. | PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal Muscle | 10.3 | Medium |
| Kidney | 8.7 | Medium |
| Liver | 4.2 | Low |
| Brain | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 11.8 | Lung cancer cell line |
| HEK 293 | 9.5 | Embryonic kidney cell line |
| MCF7 | 7.3 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | <0.1% | Unknown; predicted benign by in silico tools |
| c.456_457insA | Frameshift | <0.01% | Likely loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • focal adhesion |
| • cell adhesion | • cytoskeleton |
| • signal transduction |
Pathways
• Focal adhesion (KEGG: hsa04510)
• Integrin signaling pathway
• Regulation of actin cytoskeleton (KEGG: hsa04810)
Protein Summary
Parvin alpha is a 372-amino acid protein containing calponin homology (CH) domains that mediate actin binding. It forms a complex with ILK and PINCH at focal adhesions, linking integrins to the actin cytoskeleton. This protein is essential for cell adhesion, spreading, and migration, and its dysregulation is implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARVA Knockout HEK293 Cell Line | EDJ-KQ14687 | Human | 55742 | Details Get a Quote |
| PARVA Knockout A-549 Cell Line | EDJ-KQ44991 | Human | 55742 | Details Get a Quote |
| PARVA Knockout HCT 116 Cell Line | EDJ-KQ44992 | Human | 55742 | Details Get a Quote |
| PARVA Knockout HeLa Cell Line | EDJ-KQ44993 | Human | 55742 | Details Get a Quote |
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