PARP16
Poly(ADP-ribose) Polymerase Family Member 16
Gene Information Card
| Symbol | PARP16 |
|---|---|
| Full Name | Poly(ADP-ribose) Polymerase Family Member 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q22.31 |
| NCBI Gene ID | 54956 ncbi.nlm.nih.gov/gene/54956 |
| Ensembl ID | ENSG00000138614 |
| UniProt ID | Q8N5A5 |
| OMIM ID | 618401 |
| HGNC ID | 26818 |
| Aliases | ARTD15, pART16 |
Description
PARP16 (Poly(ADP-ribose) Polymerase Family Member 16) is a protein-coding gene located on chromosome 15q22.31. It encodes a mono-ADP-ribosyltransferase enzyme that modifies target proteins by adding a single ADP-ribose moiety. PARP16 is involved in cellular stress responses, including the unfolded protein response (UPR) and DNA damage signaling. It is also known as ARTD15 (ADP-ribosyltransferase diphtheria toxin-like 15).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | PARP16 overexpression may promote tumor cell survival under stress; potential role in DNA repair | COSMIC; literature |
| Neurodegenerative disorders | Altered ADP-ribosylation may impact protein aggregation and cellular stress pathways | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.8 | Medium |
| Thyroid | 9.2 | Medium |
| Adrenal gland | 8.5 | Medium |
| Liver | 6.1 | Low |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | High expression |
| HeLa | 12.1 | Moderate expression |
| K562 | 8.7 | Low expression |
| MCF7 | 7.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect |
| c.1012G>A (p.Gly338Arg) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • NAD+ ADP-ribosyltransferase activity (GO:0003950) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • response to endoplasmic reticulum stress (GO:0034976) |
| • protein ADP-ribosylation (GO:0006471) |
Pathways
• Unfolded Protein Response (UPR)
• ADP-ribosylation signaling
Protein Summary
PARP16 is a 322-amino acid mono-ADP-ribosyltransferase localized to the cytoplasm and nucleus. It catalyzes the transfer of ADP-ribose from NAD+ to target proteins, modulating their activity. PARP16 is implicated in the unfolded protein response (UPR) by modifying components of the endoplasmic reticulum stress pathway. Its expression is highest in testis and thyroid, with moderate levels in adrenal gland. Mutations in PARP16 are rare and of unknown clinical significance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP16 Knockout HEK293 Cell Line | EDJ-KQ13904 | Human | 54956 | Details Get a Quote |
| PARP16 Knockout A-549 Cell Line | EDJ-KQ44987 | Human | 54956 | Details Get a Quote |
| PARP16 Knockout HCT 116 Cell Line | EDJ-KQ44989 | Human | 54956 | Details Get a Quote |
| PARP16 Knockout HeLa Cell Line | EDJ-KQ44990 | Human | 54956 | Details Get a Quote |
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