PARP15: Poly(ADP-Ribose) Polymerase Family Member 15
A mono-ADP-ribosyltransferase involved in immune regulation and cancer biology
Gene Information Card
| Symbol | PARP15 |
|---|---|
| Full Name | Poly(ADP-Ribose) Polymerase Family Member 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q21.1 |
| NCBI Gene ID | 165631 ncbi.nlm.nih.gov/gene/165631 |
| Ensembl ID | ENSG00000163631 |
| UniProt ID | Q460N3 |
| OMIM ID | 612082 |
| HGNC ID | 26876 |
| Aliases | ARTD7, BAL3, PARP-15, pART7 |
Description
PARP15 (Poly(ADP-Ribose) Polymerase Family Member 15) encodes a mono-ADP-ribosyltransferase enzyme that catalyzes the transfer of ADP-ribose from NAD+ to target proteins. It belongs to the PARP family and contains a macrodomain that binds ADP-ribose. PARP15 is involved in cellular stress responses, immune signaling, and transcriptional regulation. Its expression is enriched in lymphoid tissues and it has been implicated in certain cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered PARP15 expression may affect DNA repair and cell survival pathways | COSMIC; PMID: 25686126 |
| Colorectal cancer | Mutations and copy number alterations observed in tumor samples | COSMIC; PMID: 28270531 |
| Lung adenocarcinoma | Downregulation associated with poor prognosis | PMID: 31570863 |
| Systemic lupus erythematosus | Polymorphisms in PARP15 linked to autoimmune susceptibility | PMID: 23714751 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Lung | 3.1 | Low |
| Breast | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 15.3 | High expression |
| HeLa (cervical cancer) | 4.2 | Moderate expression |
| A549 (lung cancer) | 2.1 | Low expression |
| MCF7 (breast cancer) | 1.0 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T (p.Arg375Trp) | Missense | 0.02% | Unknown functional impact |
| c.1456G>A (p.Glu486Lys) | Missense | 0.01% | Predicted damaging by SIFT |
| c.1789_1790insA | Frameshift | 0.005% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in PARP15 are predicted to truncate the catalytic domain, reducing mono-ADP-ribosyltransferase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PARP15.
Dominant Negative (DN)
No evidence of dominant-negative effects for PARP15 mutations.
View complete mutation data：
Gene Ontology (GO)
| • NAD+ ADP-ribosyltransferase activity (GO:0003950) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • protein ADP-ribosylation (GO:0006471) |
| • positive regulation of GTPase activity (GO:0043547) |
Pathways
• ADP-ribosylation of proteins
• Cellular response to stress
• Immune system signaling
Protein Summary
PARP15 is a 656-amino acid mono-ADP-ribosyltransferase with a central catalytic domain and a C-terminal macrodomain. It modifies target proteins by adding a single ADP-ribose moiety, regulating their activity in processes such as DNA damage response, chromatin remodeling, and immune signaling. PARP15 is predominantly expressed in lymphoid tissues and is implicated in cancer and autoimmune diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP15 Knockout HEK293 Cell Line | EDJ-KQ14686 | Human | 165631 | Details Get a Quote |
| PARP15 Knockout HeLa Cell Line | EDJ-KQ58890 | Human | 165631 | Details Get a Quote |
| PARP15 Knockout A-549 Cell Line | EDJ-KQ67379 | Human | 165631 | Details Get a Quote |
| PARP15 Knockout HCT 116 Cell Line | EDJ-KQ75772 | Human | 165631 | Details Get a Quote |
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