PARP14: A Multifunctional ADP-Ribosyltransferase in Immunity and Cancer
Comprehensive gene card for PARP14 (ARTD14/BAL2) covering genomic context, expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | PARP14 |
|---|---|
| Full Name | Poly(ADP-ribose) polymerase family member 14 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q21.1 |
| NCBI Gene ID | 54625 ncbi.nlm.nih.gov/gene/54625 |
| Ensembl ID | ENSG00000113721 |
| UniProt ID | Q460N5 |
| OMIM ID | 611567 |
| HGNC ID | 29232 |
| Aliases | ARTD14, BAL2, PARP-14, KIAA1268, DKFZp686B20107 |
Description
PARP14 (poly(ADP-ribose) polymerase family member 14) encodes a mono-ADP-ribosyltransferase that catalyzes the transfer of ADP-ribose from NAD+ to target proteins. It is involved in DNA damage repair, transcriptional regulation, and immune signaling. PARP14 promotes cell survival under stress and has been implicated in cancer progression, particularly in multiple myeloma, breast cancer, and lymphoma. It also plays a role in macrophage polarization and antiviral responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multiple Myeloma | PARP14 overexpression promotes survival of myeloma cells via STAT6 activation and anti-apoptotic signaling. | PMID: 23300459; NCBI GeneRIF |
| Breast Cancer | PARP14 expression correlates with poor prognosis; enhances DNA repair and chemoresistance. | PMID: 31073015; COSMIC |
| Lymphoma | PARP14 supports B-cell survival and proliferation through ADP-ribosylation of BCL6. | PMID: 23300459; UniProt |
| Viral Infection | PARP14 inhibits interferon signaling by ADP-ribosylating STAT1, promoting viral replication. | PMID: 28424240; NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Medium |
| Lung | 6.1 | Low |
| Breast | 5.3 | Low |
| Colon | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.2 | High expression |
| MCF7 (breast cancer) | 9.8 | Moderate expression |
| HeLa (cervical cancer) | 7.5 | Moderate expression |
| HepG2 (liver cancer) | 4.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.2567A>G (p.Gln856Arg) | Missense | 0.01% (gnomAD) | Reported in COSMIC; potential gain-of-function |
| c.3456_3457insA (p.Glu1153fs) | Frameshift | Rare | Loss-of-function predicted |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations (e.g., p.Glu1153fs) are predicted to truncate the catalytic domain, impairing ADP-ribosyltransferase activity.
Gain of Function (GOF)
Missense variants such as p.Gln856Arg may enhance catalytic activity or substrate interaction, though functional validation is limited.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported for PARP14.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ADP-ribosylation (Reactome: R-HSA-196854)
• DNA repair (Reactome: R-HSA-73894)
• Interferon signaling (Reactome: R-HSA-913531)
• STAT6 signaling (KEGG: hsa04630)
Protein Summary
PARP14 is a 1801-amino-acid mono-ADP-ribosyltransferase containing a WWE domain, a macrodomain, and a C-terminal catalytic PARP domain. It localizes to both nucleus and cytoplasm, where it modifies target proteins (e.g., STAT1, STAT6, BCL6) to regulate transcription, DNA repair, and immune responses. Overexpression in multiple cancers correlates with poor prognosis and therapy resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP14 Knockout HEK293 Cell Line | EDJ-KQ3727 | Human | 54625 | Details Get a Quote |
| PARP14 Knockout A-549 Cell Line | EDJ-KQ25772 | Human | 54625 | Details Get a Quote |
| PARP14 Knockout HCT 116 Cell Line | EDJ-KQ25773 | Human | 54625 | Details Get a Quote |
| PARP14 Knockout HeLa Cell Line | EDJ-KQ25774 | Human | 54625 | Details Get a Quote |
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