PARP11
Poly(ADP-ribose) Polymerase Family Member 11
Gene Information Card
| Symbol | PARP11 |
|---|---|
| Full Name | Poly(ADP-ribose) Polymerase Family Member 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.33 |
| NCBI Gene ID | 57097 ncbi.nlm.nih.gov/gene/57097 |
| Ensembl ID | ENSG00000111206 |
| UniProt ID | Q9NR21 |
| OMIM ID | 610993 |
| HGNC ID | 15676 |
| Aliases | ARTD11, PARP-11, pART11 |
Description
PARP11 (Poly(ADP-ribose) Polymerase Family Member 11) is a protein-coding gene that encodes a member of the poly(ADP-ribose) polymerase (PARP) enzyme family. PARP11 catalyzes the transfer of ADP-ribose from NAD+ to target proteins, modulating protein function and cellular signaling. It is involved in DNA repair, chromatin remodeling, and regulation of transcription. PARP11 is localized to the nucleus and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PARP11 overexpression may promote tumorigenesis via altered DNA repair | COSMIC, ClinVar |
| Ovarian cancer | Dysregulation of PARP11 expression linked to genomic instability | COSMIC |
| Neurodegenerative disorders | Potential role in PARP-mediated neuronal damage | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 5.1 | Low |
| Lung | 4.3 | Low |
| Breast | 3.9 | Low |
| Ovary | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 6.0 | Embryonic kidney cells |
| HeLa | 5.5 | Cervical cancer cells |
| MCF7 | 4.8 | Breast cancer cells |
| A549 | 4.2 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1010C>T (p.Thr337Met) | Missense | 0.01% | Unknown functional impact |
| c.1456G>A (p.Glu486Lys) | Missense | 0.005% | Potential loss of catalytic activity |
| c.1789_1791del (p.Lys597del) | In-frame deletion | 0.002% | Altered protein stability |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the catalytic domain (e.g., p.Glu486Lys) may impair ADP-ribosyltransferase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • NAD+ ADP-ribosyltransferase activity (GO:0003950) | • nucleus (GO:0005634) |
| • double-strand break repair (GO:0006302) | • protein ADP-ribosylation (GO:0006471) |
| • regulation of chromatin silencing (GO:0035064) |
Pathways
• DNA repair (PARP-dependent)
• Chromatin remodeling
• Apoptosis signaling
Protein Summary
PARP11 is a 646-amino acid nuclear protein with a conserved PARP catalytic domain. It catalyzes poly(ADP-ribosyl)ation of target proteins, influencing DNA repair, chromatin structure, and gene expression. PARP11 is expressed at low to moderate levels across tissues, with highest expression in testis. Its dysregulation is implicated in cancer and neurodegenerative diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARP11 Knockout HEK293 Cell Line | EDJ-KQ14684 | Human | 57097 | Details Get a Quote |
| PARP11 Knockout A-549 Cell Line | EDJ-KQ44982 | Human | 57097 | Details Get a Quote |
| PARP11 Knockout HCT 116 Cell Line | EDJ-KQ44983 | Human | 57097 | Details Get a Quote |
| PARP11 Knockout HeLa Cell Line | EDJ-KQ56801 | Human | 57097 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
