PARM1: Prostate Androgen-Regulated Mucin-Like Protein 1
A comprehensive genomic and proteomic overview of PARM1, including gene function, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | PARM1 |
|---|---|
| Full Name | Prostate Androgen-Regulated Mucin-Like Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.22 |
| NCBI Gene ID | 25849 ncbi.nlm.nih.gov/gene/25849 |
| Ensembl ID | ENSG00000138669 |
| UniProt ID | Q6UWB1 |
| OMIM ID | 617768 |
| HGNC ID | 24536 |
| Aliases | C4orf2, MGC129647, MGC129648, PARM-1 |
Description
PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1) is a protein-coding gene located on chromosome 4q21.22. It encodes a mucin-like protein that is upregulated by androgens in prostate cells. PARM1 is involved in cell adhesion, migration, and may play a role in prostate cancer progression. Its expression is also detected in various normal and malignant tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | PARM1 is upregulated by androgens and may promote tumor cell migration and invasion. | PMID: 15626734, PMID: 20628086 |
| Breast cancer | Overexpression observed in some breast cancer cell lines; potential role in metastasis. | PMID: 20628086 |
| Colorectal cancer | Altered expression reported; functional significance under investigation. | PMID: 20628086 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 6.1 | Low |
| Lung | 4.7 | Low |
| Kidney | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 15.2 | Androgen-responsive; high PARM1 expression |
| MCF-7 (breast cancer) | 9.8 | Moderate expression |
| HT-29 (colorectal cancer) | 7.4 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T | Missense | <0.1% | p.Arg163Cys; unknown significance |
| c.632A>G | Missense | <0.1% | p.Asn211Ser; unknown significance |
| c.1045G>A | Missense | <0.1% | p.Val349Ile; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PARM1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PARM1.
Dominant Negative (DN)
No dominant-negative mutations reported in PARM1.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • extracellular space (GO:0005615) |
| • cell adhesion (GO:0007155) | • cell migration (GO:0016477) |
| • cell differentiation (GO:0030154) |
Pathways
• Androgen receptor signaling pathway
• Cell adhesion molecules (CAMs)
Protein Summary
PARM1 encodes a mucin-like protein that is secreted and localized to the extracellular region. It is involved in cell adhesion and migration, and its expression is regulated by androgens. The protein may contribute to tumor progression in prostate and other cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARM1 Knockout HEK293 Cell Line | EDJ-KQ8263 | Human | 25849 | Details Get a Quote |
| PARM1 Knockout A-549 Cell Line | EDJ-KQ34201 | Human | 25849 | Details Get a Quote |
| PARM1 Knockout HCT 116 Cell Line | EDJ-KQ34202 | Human | 25849 | Details Get a Quote |
| PARM1 Knockout HeLa Cell Line | EDJ-KQ55831 | Human | 25849 | Details Get a Quote |
