PARD6B
Par-6 Family Cell Polarity Regulator Beta
Gene Information Card
| Symbol | PARD6B |
|---|---|
| Full Name | Par-6 Family Cell Polarity Regulator Beta |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.13 |
| NCBI Gene ID | 84612 ncbi.nlm.nih.gov/gene/84612 |
| Ensembl ID | ENSG00000124120 |
| UniProt ID | Q9BYG4 |
| OMIM ID | 608974 |
| HGNC ID | 16253 |
| Aliases | PAR-6B, PAR6B, PAR6GAMMA |
Description
PARD6B encodes a member of the Par-6 family of cell polarity regulators. The protein is a cytoplasmic adaptor that forms a complex with atypical protein kinase C (aPKC) and other Par proteins to establish and maintain cell polarity, particularly in epithelial tight junctions and asymmetric cell division. It is involved in cellular processes such as migration, proliferation, and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered PARD6B expression disrupts tight junction integrity and polarity, promoting invasion | PMID: 21947068 |
| Lung cancer | PARD6B overexpression correlates with poor prognosis and enhanced cell migration | PMID: 25605248 |
| Colorectal cancer | Loss of PARD6B expression linked to epithelial-mesenchymal transition (EMT) | PMID: 27323850 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.7 | Low |
| Colon | 5.9 | Low |
| Kidney | 10.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 8.5 | Moderate expression |
| A549 (lung cancer) | 7.2 | Low expression |
| HCT116 (colorectal cancer) | 6.0 | Low expression |
| HEK293 (embryonic kidney) | 11.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | <0.01% | Unknown functional impact |
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Potential loss of polarity function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may disrupt Par-6/aPKC complex formation, impairing cell polarity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • cell polarity | • tight junction assembly |
| • asymmetric cell division | • protein kinase C binding |
| • cytoplasm | • cell-cell junction |
Pathways
• Par-6/aPKC polarity pathway
• Tight junction signaling
• Asymmetric cell division
Protein Summary
PARD6B is a 376-amino acid protein containing a PDZ domain and a CRIB motif. It functions as a scaffold that recruits aPKC to cell polarity complexes, regulating tight junction formation and asymmetric cell division. The protein is widely expressed in epithelial tissues and is implicated in cancer progression when dysregulated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PARD6B Knockout HEK293 Cell Line | EDJ-KQ1344 | Human | 84612 | Details Get a Quote |
| PARD6B Knockout HCT 116 Cell Line | EDJ-KQ19470 | Human | 84612 | Details Get a Quote |
| PARD6B Knockout A-549 Cell Line | EDJ-KQ20813 | Human | 84612 | Details Get a Quote |
| PARD6B Knockout HeLa Cell Line | EDJ-KQ20814 | Human | 84612 | Details Get a Quote |
