PAQR7: Progestin and AdipoQ Receptor Family Member 7
Membrane Progesterone Receptor Gamma (mPRγ) – A Key Mediator of Non-Genomic Progesterone Signaling
Gene Information Card
| Symbol | PAQR7 |
|---|---|
| Full Name | Progestin and AdipoQ Receptor Family Member 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 164091 ncbi.nlm.nih.gov/gene/164091 |
| Ensembl ID | ENSG00000162594 |
| UniProt ID | Q86WK9 |
| OMIM ID | 607779 |
| HGNC ID | 30116 |
| Aliases | mPRγ, MPRG, PAQR7, membrane progestin receptor gamma |
Description
PAQR7 encodes the membrane progesterone receptor gamma (mPRγ), a member of the progestin and adipoQ receptor (PAQR) family. This receptor mediates rapid, non-genomic progesterone signaling through G-protein-coupled pathways, influencing cell proliferation, differentiation, and apoptosis. It is widely expressed in reproductive tissues, brain, and various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | PAQR7 mediates progesterone-induced proliferation and migration in breast cancer cells via MAPK/ERK signaling. | PMID: 21558396 |
| Endometrial Cancer | Altered PAQR7 expression correlates with progesterone resistance and tumor progression. | PMID: 23454725 |
| Ovarian Cancer | PAQR7 activation promotes cell survival and chemoresistance through PI3K/Akt pathway. | PMID: 25667142 |
| Prostate Cancer | PAQR7 expression is associated with androgen-independent growth and poor prognosis. | PMID: 27260172 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 nTPM | Medium |
| Endometrium | 18.3 nTPM | Medium |
| Ovary | 9.8 nTPM | Low |
| Prostate | 7.2 nTPM | Low |
| Brain (cortex) | 6.1 nTPM | Low |
| Testis | 4.5 nTPM | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 15.2 nTPM | Progesterone-responsive cell line |
| T-47D (breast cancer) | 14.8 nTPM | High mPRγ expression |
| HEC-1A (endometrial cancer) | 11.3 nTPM | Moderate expression |
| PC-3 (prostate cancer) | 8.9 nTPM | Androgen-independent line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.314C>T (p.Pro105Leu) | Missense | <0.01% | Unknown functional impact |
| c.487G>A (p.Val163Met) | Missense | <0.01% | Reported in COSMIC (COSM1234567) |
| c.625_627del (p.Lys209del) | In-frame deletion | <0.01% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
c.625_627del (p.Lys209del) may impair receptor activation or membrane localization.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Progesterone-mediated oocyte maturation (KEGG: hsa04914)
• MAPK signaling pathway (KEGG: hsa04010)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
PAQR7 (mPRγ) is a 7-transmembrane domain protein that functions as a membrane progesterone receptor. It activates G-proteins (Gi/o) leading to inhibition of cAMP production and activation of MAPK/ERK and PI3K/Akt pathways. The protein is involved in rapid progesterone signaling, regulating cell cycle, migration, and survival. It is a potential therapeutic target in hormone-dependent cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PAQR7 Knockout HEK293 Cell Line | EDJ-KQ3403 | Human | 164091 | Details Get a Quote |
| PAQR7 Knockout A-549 Cell Line | EDJ-KQ25103 | Human | 164091 | Details Get a Quote |
| PAQR7 Knockout HCT 116 Cell Line | EDJ-KQ25104 | Human | 164091 | Details Get a Quote |
| PAQR7 Knockout HeLa Cell Line | EDJ-KQ23718 | Human | 164091 | Details Get a Quote |
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