PAQR3: Progestin and AdipoQ Receptor Family Member 3
A tumor suppressor gene encoding a membrane receptor involved in metabolic signaling and cancer progression.
Gene Information Card
| Symbol | PAQR3 |
|---|---|
| Full Name | Progestin and AdipoQ Receptor Family Member 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.21 |
| NCBI Gene ID | 152559 ncbi.nlm.nih.gov/gene/152559 |
| Ensembl ID | ENSG00000164124 |
| UniProt ID | Q6TCH7 |
| OMIM ID | 614794 |
| HGNC ID | 30149 |
| Aliases | MGC13170, RKTG, PAQR3 |
Description
PAQR3 (Progestin and AdipoQ Receptor Family Member 3) is a protein-coding gene that encodes a member of the progestin and adipoQ receptor (PAQR) family. The protein is a membrane receptor involved in metabolic signaling, particularly in the regulation of glucose and lipid metabolism. PAQR3 functions as a tumor suppressor by modulating the PI3K/AKT and MAPK signaling pathways. It is frequently downregulated in various cancers, including gastric, colorectal, and breast cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric Cancer | Downregulation of PAQR3 leads to increased PI3K/AKT signaling and cell proliferation. | PMID: 23454731 |
| Colorectal Cancer | Loss of PAQR3 expression correlates with poor prognosis and enhanced metastasis. | PMID: 25642769 |
| Breast Cancer | PAQR3 suppresses tumor growth by inhibiting the MAPK pathway. | PMID: 27134142 |
| Hepatocellular Carcinoma | PAQR3 acts as a tumor suppressor by promoting apoptosis and inhibiting angiogenesis. | PMID: 28341828 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Heart | 6.1 | Low |
| Brain | 4.2 | Low |
| Testis | 15.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| MCF7 | 5.4 | Breast cancer cells |
| HepG2 | 9.1 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | p.Met1Val; potential loss of start codon |
| c.100C>T | Nonsense | <0.1% | p.Arg34*; premature truncation |
| c.200_201insA | Frameshift | <0.1% | p.Gln67fs; loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in PAQR3 result in truncated proteins lacking functional domains, leading to loss of tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for PAQR3.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for PAQR3.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • membrane |
| • signal transduction | • negative regulation of cell proliferation |
| • positive regulation of apoptosis |
Pathways
• PI3K-Akt signaling pathway
• MAPK signaling pathway
• Adipocytokine signaling pathway
Protein Summary
The PAQR3 protein is a 311-amino acid membrane receptor with seven transmembrane domains. It belongs to the progestin and adipoQ receptor family and is localized to the plasma membrane. The protein functions as a tumor suppressor by negatively regulating the PI3K/AKT and MAPK signaling cascades. It also plays a role in metabolic homeostasis by modulating insulin sensitivity and lipid metabolism. PAQR3 is widely expressed in human tissues, with highest levels in liver and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PAQR3 Knockout HEK293 Cell Line | EDJ-KQ11414 | Human | 152559 | Details Get a Quote |
| PAQR3 Knockout A-549 Cell Line | EDJ-KQ39647 | Human | 152559 | Details Get a Quote |
| PAQR3 Knockout HCT 116 Cell Line | EDJ-KQ39648 | Human | 152559 | Details Get a Quote |
| PAQR3 Knockout HeLa Cell Line | EDJ-KQ39649 | Human | 152559 | Details Get a Quote |
