PANO1: Proapoptotic Nucleolar Protein 1
A comprehensive resource for PANO1 gene information, including genomic context, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | PANO1 |
|---|---|
| Full Name | proapoptotic nucleolar protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | A0A1B0GTV8 |
| OMIM ID | 619847 |
| HGNC ID | 53887 |
| Aliases | C11orf84, MGC16384, PANO1 |
Description
PANO1 (proapoptotic nucleolar protein 1) is a protein-coding gene located on chromosome 11p15.5. It encodes a nucleolar protein involved in the regulation of apoptosis. PANO1 is implicated in cellular stress responses and has been studied in the context of cancer, where its expression may influence tumor progression and treatment response.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | PANO1 expression is altered in various cancers; may modulate apoptosis in tumor cells. | NCBI Gene, COSMIC |
| Colorectal cancer | Differential expression of PANO1 observed; potential role in apoptosis regulation. | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Lymph node | 3.8 | Low |
| Spleen | 2.9 | Low |
| Bone marrow | 2.1 | Low |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.5 | Low expression |
| HeLa | 0.8 | Very low |
| K562 | 2.3 | Low |
| MCF7 | 1.1 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Rare | Unknown functional impact |
| c.100C>T | missense | Rare | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • nucleolus (GO:0005730) | • apoptotic process (GO:0006915) |
| • positive regulation of apoptotic process (GO:0043065) |
Pathways
• Apoptosis - intrinsic pathway (inferred from GO annotations)
Protein Summary
PANO1 is a small nucleolar protein (approximately 15 kDa) that localizes to the nucleolus. It is involved in promoting apoptosis, likely through interactions with nucleolar stress pathways. The protein contains a conserved domain of unknown function (DUF). Its precise molecular mechanism remains under investigation, but it is thought to sensitize cells to apoptotic stimuli.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PANO1 Knockout HEK293 Cell Line | EDJ-KQ14672 | Human | 101927423 | Details Get a Quote |
| PANO1 Knockout HeLa Cell Line | EDJ-KQ43741 | Human | 101927423 | Details Get a Quote |
| PANO1 Knockout A-549 Cell Line | EDJ-KQ44960 | Human | 101927423 | Details Get a Quote |
| PANO1 Knockout HCT 116 Cell Line | EDJ-KQ44961 | Human | 101927423 | Details Get a Quote |
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