PAIP2B
Poly(A) Binding Protein Interacting Protein 2B
Gene Information Card
| Symbol | PAIP2B |
|---|---|
| Full Name | Poly(A) Binding Protein Interacting Protein 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 2p13.3 |
| NCBI Gene ID | 400961 ncbi.nlm.nih.gov/gene/400961 |
| Ensembl ID | ENSG00000163026 |
| UniProt ID | Q9ULR5 |
| OMIM ID | 615205 |
| HGNC ID | 26343 |
| Aliases | PAIP2B, FLJ11273 |
Description
PAIP2B encodes a protein that interacts with poly(A)-binding protein (PABP) and inhibits its activity, thereby regulating translation initiation and mRNA stability. The gene is located on chromosome 2p13.3 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • translation regulator activity | • mRNA binding |
| • cytoplasm |
Pathways
• mRNA surveillance pathway
• Translation regulation
Protein Summary
PAIP2B is a 509-amino acid protein that binds to poly(A)-binding protein (PABP) and inhibits its interaction with poly(A) tails, thereby repressing translation initiation. It is localized in the cytoplasm and plays a role in post-transcriptional gene regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PAIP2B Knockout HEK293 Cell Line | EDJ-KQ11604 | Human | 400961 | Details Get a Quote |
| PAIP2B Knockout HCT 116 Cell Line | EDJ-KQ39946 | Human | 400961 | Details Get a Quote |
| PAIP2B Knockout HeLa Cell Line | EDJ-KQ60283 | Human | 400961 | Details Get a Quote |
| PAIP2B Knockout A-549 Cell Line | EDJ-KQ68745 | Human | 400961 | Details Get a Quote |
