PAIP2: Poly(A) Binding Protein Interacting Protein 2
A key regulator of mRNA translation and poly(A) tail length
Gene Information Card
| Symbol | PAIP2 |
|---|---|
| Full Name | Poly(A) Binding Protein Interacting Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 51247 ncbi.nlm.nih.gov/gene/51247 |
| Ensembl ID | ENSG00000113522 |
| UniProt ID | Q9BPZ3 |
| OMIM ID | 609394 |
| HGNC ID | 28745 |
| Aliases | PAIP2A, MGC2615 |
Description
PAIP2 encodes poly(A) binding protein interacting protein 2, a negative regulator of translation. It binds to poly(A)-binding protein (PABPC1) and inhibits its interaction with the poly(A) tail of mRNA, thereby repressing translation initiation and promoting mRNA deadenylation. PAIP2 is involved in the regulation of gene expression at the post-transcriptional level and plays a role in cellular processes such as proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney cells |
| HeLa | 8.7 | Cervical carcinoma cells |
| K562 | 6.5 | Leukemia cells |
| HepG2 | 5.1 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Not reported in COSMIC | Unknown |
| c.100C>T | Nonsense | Not reported in COSMIC | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
No validated loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No validated gain-of-function mutations reported.
Dominant Negative (DN)
No validated dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• mRNA deadenylation (Reactome: R-HSA-429947)
• Translation regulation by PABP (Reactome: R-HSA-156827)
Protein Summary
PAIP2 is a 127-amino acid protein that contains a PABP-interacting motif. It competes with PABPC1 for binding to the poly(A) tail, leading to translational repression and mRNA decay. The protein is widely expressed, with highest levels in testis. Its structure includes a conserved PAIP2 domain essential for PABPC1 interaction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PAIP2 Knockout HEK293 Cell Line | EDJ-KQ2133 | Human | 51247 | Details Get a Quote |
| PAIP2B Knockout HEK293 Cell Line | EDJ-KQ11604 | Human | 400961 | Details Get a Quote |
| PAIP2 Knockout HCT 116 Cell Line | EDJ-KQ20987 | Human | 51247 | Details Get a Quote |
| PAIP2B Knockout HCT 116 Cell Line | EDJ-KQ39946 | Human | 400961 | Details Get a Quote |
| PAIP2 Knockout A-549 Cell Line | EDJ-KQ22294 | Human | 51247 | Details Get a Quote |
| PAIP2 Knockout HeLa Cell Line | EDJ-KQ22295 | Human | 51247 | Details Get a Quote |
| PAIP2B Knockout HeLa Cell Line | EDJ-KQ60283 | Human | 400961 | Details Get a Quote |
| PAIP2B Knockout A-549 Cell Line | EDJ-KQ68745 | Human | 400961 | Details Get a Quote |
