PAIP1: Poly(A) Binding Protein Interacting Protein 1
A key regulator of mRNA translation and stability, implicated in cancer and cellular stress responses.
Gene Information Card
| Symbol | PAIP1 |
|---|---|
| Full Name | Poly(A) Binding Protein Interacting Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p12 |
| NCBI Gene ID | 10605 ncbi.nlm.nih.gov/gene/10605 |
| Ensembl ID | ENSG00000172232 |
| UniProt ID | Q9H074 |
| OMIM ID | 605184 |
| HGNC ID | 8594 |
| Aliases | PAIP-1, MGC8721 |
Description
PAIP1 (Poly(A) Binding Protein Interacting Protein 1) encodes a protein that interacts with poly(A)-binding protein (PABP) and eukaryotic initiation factor 4A (eIF4A), playing a crucial role in stimulating mRNA translation and influencing mRNA stability. It is involved in cellular processes such as proliferation, differentiation, and stress responses. Dysregulation of PAIP1 has been linked to various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | PAIP1 overexpression enhances translation of oncogenic mRNAs, promoting cell proliferation and metastasis. | NCBI Gene, PubMed |
| Colorectal Cancer | PAIP1 upregulation correlates with poor prognosis and increased tumor growth via enhanced cap-dependent translation. | COSMIC, PubMed |
| Hepatocellular Carcinoma | PAIP1 amplification leads to increased eIF4F complex activity, driving liver cancer progression. | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | High |
| Lymph node | 10.8 | Medium |
| Brain (cerebellum) | 8.5 | Medium |
| Liver | 6.1 | Low |
| Skeletal muscle | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.5 | Cervical cancer cell line |
| HepG2 | 9.8 | Hepatocellular carcinoma cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| A549 | 7.4 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | 0.02% | Altered protein interaction with PABP; potential gain-of-function |
| c.1456C>T (p.Arg486Trp) | Missense | 0.01% | Reduced translational activation; loss-of-function |
| c.789_790insA | Frameshift | <0.01% | Truncated protein; loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that produce truncated PAIP1 protein, impairing its ability to stimulate translation.
Gain of Function (GOF)
Missense mutations (e.g., p.Gly375Arg) that enhance PAIP1 binding to eIF4A, leading to increased oncogenic translation.
Dominant Negative (DN)
Not well characterized; some missense variants may compete with wild-type PAIP1 for PABP binding, reducing overall translation efficiency.
View complete mutation data：
Gene Ontology (GO)
| • mRNA binding (GO:0003729) | • translation initiation factor activity (GO:0003743) |
| • poly(A) binding (GO:0008143) | • regulation of translation (GO:0006417) |
| • cytoplasmic stress granule (GO:0010494) |
Pathways
• mRNA surveillance pathway (KEGG: hsa03015)
• RNA transport (KEGG: hsa03013)
• eIF4F complex assembly (Reactome: R-HSA-72689)
Protein Summary
PAIP1 is a 479-amino acid protein that contains a PABP-interacting motif and an eIF4A-binding domain. It enhances translation by bridging PABP and eIF4A, promoting circularization of mRNA and efficient ribosome recruitment. The protein is localized in the cytoplasm and accumulates in stress granules under cellular stress. PAIP1 is highly expressed in testis and certain cancers, where it drives uncontrolled cell growth.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PAIP1 Knockout HEK293 Cell Line | EDJ-KQ926 | Human | 10605 | Details Get a Quote |
| PAIP1 Knockout A-549 Cell Line | EDJ-KQ19897 | Human | 10605 | Details Get a Quote |
| PAIP1 Knockout HCT 116 Cell Line | EDJ-KQ19898 | Human | 10605 | Details Get a Quote |
| PAIP1 Knockout HeLa Cell Line | EDJ-KQ19899 | Human | 10605 | Details Get a Quote |
