PABPC4: Poly(A) Binding Protein Cytoplasmic 4
A key regulator of mRNA stability and translation initiation, implicated in cancer and viral infections.
Gene Information Card
| Symbol | PABPC4 |
|---|---|
| Full Name | Poly(A) Binding Protein Cytoplasmic 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p34.3 |
| NCBI Gene ID | 8761 ncbi.nlm.nih.gov/gene/8761 |
| Ensembl ID | ENSG00000130684 |
| UniProt ID | Q13310 |
| OMIM ID | 603407 |
| HGNC ID | 8556 |
| Aliases | PABP4, iPABP, PABPC4L |
Description
PABPC4 encodes a member of the poly(A)-binding protein family, which binds to the poly(A) tail of mRNA and plays a critical role in mRNA stability, translation initiation, and polyadenylation. The protein is predominantly cytoplasmic and is involved in regulating gene expression at the post-transcriptional level. PABPC4 is also implicated in cellular responses to viral infections and in cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of PABPC4 enhances mRNA stability of oncogenes, promoting cell proliferation. | PMID: 25691885 |
| Colorectal cancer | PABPC4 upregulation correlates with poor prognosis and increased metastatic potential. | PMID: 29736038 |
| HIV-1 infection | PABPC4 interacts with HIV-1 Rev protein to facilitate nuclear export of viral mRNA. | PMID: 22114356 |
| Influenza A infection | PABPC4 is hijacked by influenza virus to enhance viral mRNA translation. | PMID: 23345592 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 52.3 | High |
| Lymph node | 38.7 | High |
| Spleen | 35.1 | High |
| Bone marrow | 30.5 | High |
| Brain | 12.4 | Medium |
| Liver | 8.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 45.6 | High expression |
| HeLa | 38.2 | High expression |
| MCF7 | 32.1 | High expression |
| HepG2 | 22.5 | Medium expression |
| K562 | 18.9 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Predicted loss of function; truncation of RNA-binding domain |
| c.890_891insA | Frameshift | <0.01% | Loss of function; premature stop codon |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in PABPC4 are predicted to cause loss of function by truncating the protein, impairing mRNA binding and translation regulation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PABPC4.
Dominant Negative (DN)
No evidence for dominant-negative effects in PABPC4.
View complete mutation data：
Gene Ontology (GO)
| • mRNA binding (GO:0003729) | • poly(A) RNA binding (GO:0044822) |
| • translation initiation factor activity (GO:0003743) | • cytoplasm (GO:0005737) |
| • P-body (GO:0000932) | • regulation of translation (GO:0006417) |
| • mRNA stabilization (GO:0048255) |
Pathways
• mRNA surveillance pathway (KEGG: hsa03015)
• RNA transport (KEGG: hsa03013)
• Translation factors (Reactome: R-HSA-156842)
Protein Summary
PABPC4 is a 644-amino acid protein containing four RNA recognition motifs (RRMs) and a C-terminal domain. It binds with high affinity to poly(A) tails of mRNA, promoting circularization of mRNA via interaction with eIF4G and enhancing translation initiation. PABPC4 also shuttles between nucleus and cytoplasm and is involved in stress granule assembly. Its expression is ubiquitous but enriched in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PABPC4 Knockout HEK293 Cell Line | EDJ-KQ6352 | Human | 8761 | Details Get a Quote |
| PABPC4L Knockout HEK293 Cell Line | EDJ-KQ9296 | Human | 132430 | Details Get a Quote |
| PABPC4 Knockout HCT 116 Cell Line | EDJ-KQ28997 | Human | 8761 | Details Get a Quote |
| PABPC4 Knockout A-549 Cell Line | EDJ-KQ30305 | Human | 8761 | Details Get a Quote |
| PABPC4 Knockout HeLa Cell Line | EDJ-KQ30306 | Human | 8761 | Details Get a Quote |
| PABPC4L Knockout HeLa Cell Line | EDJ-KQ34667 | Human | 132430 | Details Get a Quote |
| PABPC4L Knockout A-549 Cell Line | EDJ-KQ66803 | Human | 132430 | Details Get a Quote |
| PABPC4L Knockout HCT 116 Cell Line | EDJ-KQ75203 | Human | 132430 | Details Get a Quote |
