P2RY6
P2Y Receptor Family Member 6
Gene Information Card
| Symbol | P2RY6 |
|---|---|
| Full Name | Pyrimidinergic Receptor P2Y6 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 5031 ncbi.nlm.nih.gov/gene/5031 |
| Ensembl ID | ENSG00000171631 |
| UniProt ID | Q15077 |
| OMIM ID | 602639 |
| HGNC ID | 8542 |
| Aliases | P2Y6, P2Y6R |
Description
P2RY6 encodes a G protein-coupled receptor (GPCR) for uridine diphosphate (UDP). It is involved in immune regulation, inflammation, and phagocytosis. Activation of P2RY6 by UDP stimulates phospholipase C and intracellular calcium mobilization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | P2RY6 activation promotes pro-inflammatory cytokine release | PMID: 28854169 |
| Atherosclerosis | Receptor mediates macrophage foam cell formation | PMID: 25245629 |
| Colorectal cancer | Overexpression linked to tumor progression and metastasis | PMID: 30523248 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 8.2 | Medium |
| Lung | 6.5 | Medium |
| Small intestine | 5.1 | Low |
| Colon | 4.8 | Low |
| Whole blood | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 12.3 | High expression |
| HUVEC (endothelial) | 7.8 | Medium expression |
| HEK293 | 2.1 | Low expression |
| Caco-2 (colon) | 5.4 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Val153Met) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • UDP receptor activity |
| • positive regulation of cytosolic calcium ion concentration | • inflammatory response |
| • phagocytosis |
Pathways
• P2Y receptors
• GPCR downstream signaling
• UDP signaling
Protein Summary
P2RY6 is a 328-amino acid GPCR with seven transmembrane domains. It binds extracellular UDP and couples to Gq/11 proteins, leading to phospholipase C activation and calcium mobilization. The receptor is expressed on immune cells and epithelial cells, playing roles in chemotaxis, cytokine release, and phagocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| P2RY6 Knockout HEK293 Cell Line | EDJ-KQ5394 | Human | 5031 | Details Get a Quote |
| P2RY6 Knockout A-549 Cell Line | EDJ-KQ28534 | Human | 5031 | Details Get a Quote |
| P2RY6 Knockout HeLa Cell Line | EDJ-KQ28535 | Human | 5031 | Details Get a Quote |
| P2RY6 Knockout HCT 116 Cell Line | EDJ-KQ71029 | Human | 5031 | Details Get a Quote |
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