P2RY14
Purinergic Receptor P2Y14
Gene Information Card
| Symbol | P2RY14 |
|---|---|
| Full Name | Purinergic Receptor P2Y14 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q25.2 |
| NCBI Gene ID | 9934 ncbi.nlm.nih.gov/gene/9934 |
| Ensembl ID | ENSG00000174944 |
| UniProt ID | Q15391 |
| OMIM ID | 600041 |
| HGNC ID | 8539 |
| Aliases | GPR105, P2Y14, P2Y14 receptor |
Description
P2RY14 encodes the P2Y14 receptor, a G protein-coupled receptor (GPCR) that is activated by UDP-glucose and other UDP-sugars. It is involved in immune cell chemotaxis, inflammatory responses, and hematopoietic stem cell regulation. The receptor is expressed in various tissues including placenta, adipose tissue, and immune cells, and has been implicated in asthma, diabetes, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | P2RY14 activation on airway epithelial cells promotes chemokine release and eosinophil recruitment, contributing to airway inflammation. | ClinVar, NCBI Gene |
| Type 2 Diabetes | P2RY14 expression in pancreatic beta cells modulates insulin secretion; variants may alter glucose homeostasis. | NCBI Gene, OMIM |
| Chronic Obstructive Pulmonary Disease (COPD) | Receptor upregulation in lung tissue correlates with neutrophil infiltration and mucus hypersecretion. | NCBI Gene |
| Acute Myeloid Leukemia | P2RY14 is overexpressed in leukemic stem cells and may support self-renewal via UDP-sugar signaling. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 16.3 | Medium |
| Adipose tissue | 12.1 | Medium |
| Lung | 8.5 | Low |
| Spleen | 7.2 | Low |
| Bone marrow | 6.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 9.4 | High expression after differentiation |
| A549 (lung epithelial) | 5.2 | Moderate expression |
| K562 (leukemia) | 3.1 | Low expression |
| HepG2 (liver) | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | <0.01% | Unknown; predicted benign by SIFT |
| c.556G>A (p.Val186Ile) | missense | <0.01% | Unknown; predicted tolerated |
| c.898C>T (p.Arg300*) | nonsense | <0.01% | Loss of function; likely pathogenic |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutation p.Arg300* truncates the receptor, likely abolishing signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • UDP-glucose receptor activity |
| • signal transduction | • chemotaxis |
| • inflammatory response | • positive regulation of cytosolic calcium ion concentration |
Pathways
• P2Y receptors
• GPCR downstream signaling
• UDP-sugar signaling in immune cells
Protein Summary
The P2Y14 receptor is a 338-amino acid GPCR with seven transmembrane domains. It is activated by UDP-glucose, UDP-galactose, and other UDP-sugars. Upon ligand binding, it couples to Gαi/o proteins, inhibiting adenylyl cyclase and mobilizing intracellular calcium. The receptor plays roles in immune cell migration, hematopoietic stem cell maintenance, and inflammatory cytokine production. Its expression is regulated in response to stress and differentiation signals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| P2RY14 Knockout HEK293 Cell Line | EDJ-KQ6825 | Human | 9934 | Details Get a Quote |
| P2RY14 Knockout HeLa Cell Line | EDJ-KQ55279 | Human | 9934 | Details Get a Quote |
| P2RY14 Knockout A-549 Cell Line | EDJ-KQ63760 | Human | 9934 | Details Get a Quote |
| P2RY14 Knockout HCT 116 Cell Line | EDJ-KQ72219 | Human | 9934 | Details Get a Quote |
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