P2RY13
Purinergic Receptor P2Y13
Gene Information Card
| Symbol | P2RY13 |
|---|---|
| Full Name | Purinergic Receptor P2Y13 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q25.1 |
| NCBI Gene ID | 53829 ncbi.nlm.nih.gov/gene/53829 |
| Ensembl ID | ENSG00000181631 |
| UniProt ID | Q9BPV8 |
| OMIM ID | 600041 |
| HGNC ID | 8537 |
| Aliases | P2Y13, GPR86, SP174, FKSG77 |
Description
P2RY13 encodes the P2Y13 receptor, a G protein-coupled receptor (GPCR) activated by extracellular ADP. It is involved in purinergic signaling, regulating processes such as platelet aggregation, immune response, and lipid metabolism. The receptor is expressed in various tissues including brain, spleen, and liver.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atherosclerosis | P2Y13 modulates HDL uptake and cholesterol efflux in hepatocytes; altered signaling may promote foam cell formation. | PMID: 19008400 |
| Thrombosis | ADP-mediated P2Y13 activation contributes to platelet aggregation and thrombus formation. | PMID: 12515819 |
| Neuropathic Pain | P2Y13 expressed in spinal microglia; activation contributes to pain hypersensitivity. | PMID: 20554836 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Spleen | 8.5 | Medium |
| Liver | 6.1 | Low |
| Lung | 4.3 | Low |
| Heart | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.5 | High expression in transfected cells |
| HepG2 | 7.8 | Endogenous expression |
| THP-1 | 5.4 | Monocytic cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.01% | Reduced receptor activity in vitro |
| c.457G>A (p.Val153Met) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Arg34Cys reduces ADP-induced signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • ADP receptor activity |
| • signal transduction | • positive regulation of cytosolic calcium ion concentration |
| • inflammatory response |
Pathways
• Purinergic signaling
• Platelet activation
• GPCR downstream signaling
Protein Summary
The P2Y13 receptor is a 333-amino acid protein with seven transmembrane domains. It couples primarily to Gi/o proteins, inhibiting adenylyl cyclase and mobilizing intracellular calcium. The receptor is critical for ADP-mediated physiological responses, including platelet aggregation and hepatic HDL metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| P2RY13 Knockout HEK293 Cell Line | EDJ-KQ51354 | Human | 53829 | Details Get a Quote |
| P2RY13 Knockout HeLa Cell Line | EDJ-KQ56381 | Human | 53829 | Details Get a Quote |
| P2RY13 Knockout A-549 Cell Line | EDJ-KQ64872 | Human | 53829 | Details Get a Quote |
| P2RY13 Knockout HCT 116 Cell Line | EDJ-KQ73317 | Human | 53829 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
