P2RY11
Purinergic Receptor P2Y11
Gene Information Card
| Symbol | P2RY11 |
|---|---|
| Full Name | Purinergic Receptor P2Y11 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 5032 ncbi.nlm.nih.gov/gene/5032 |
| Ensembl ID | ENSG00000176105 |
| UniProt ID | Q96G91 |
| OMIM ID | 602242 |
| HGNC ID | 8541 |
| Aliases | P2Y11, P2Y11 receptor |
Description
P2RY11 encodes the P2Y11 receptor, a G protein-coupled receptor (GPCR) activated by extracellular ATP and UTP. It plays roles in immune cell chemotaxis, cytokine release, and modulation of inflammation. The receptor couples primarily to Gq and Gs proteins, leading to intracellular calcium mobilization and cAMP accumulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | P2RY11 overexpression may promote leukemic cell survival via cAMP signaling | PMID: 21540177 |
| Chronic lymphocytic leukemia | Altered P2RY11 expression linked to B-cell receptor signaling | PMID: 23493551 |
| Inflammatory bowel disease | P2RY11 variants associated with altered immune response | PMID: 25915584 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.3 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.5 | Medium |
| Lung | 4.2 | Low |
| Liver | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.6 | High expression |
| Jurkat (T-cell) | 9.8 | Medium expression |
| K562 (erythroleukemia) | 6.3 | Low expression |
| HEK293 | 2.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Reduced ATP binding affinity |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Altered G protein coupling |
Mutation functional classification
Loss of Function (LOF)
p.Arg34Trp reduces receptor activation by ATP
Gain of Function (GOF)
None reported
Dominant Negative (DN)
None reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • extracellular ATP-gated cation channel activity (GO:0004931) |
| • cellular response to ATP (GO:0071318) | • inflammatory response (GO:0006954) |
| • positive regulation of cAMP-mediated signaling (GO:0030819) |
Pathways
• Purinergic signaling (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• cAMP signaling pathway (KEGG: hsa04024)
Protein Summary
P2Y11 is a 374-amino acid GPCR with seven transmembrane domains. It is activated by extracellular ATP and UTP, leading to Gq/11-mediated phospholipase C activation and Gs-mediated adenylyl cyclase activation. The receptor is expressed predominantly in immune tissues and modulates chemotaxis, cytokine production, and cell survival. Mutations affecting ATP binding or G protein coupling are rare but may alter immune function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| P2RY11 Knockout HEK293 Cell Line | EDJ-KQ50498 | Human | 5032 | Details Get a Quote |
| PPAN-P2RY11 Knockout HEK293 Cell Line | EDJ-KQ52396 | Human | 692312 | Details Get a Quote |
| P2RY11 Knockout HeLa Cell Line | EDJ-KQ54071 | Human | 5032 | Details Get a Quote |
| PPAN-P2RY11 Knockout HeLa Cell Line | EDJ-KQ60674 | Human | 692312 | Details Get a Quote |
| P2RY11 Knockout A-549 Cell Line | EDJ-KQ62559 | Human | 5032 | Details Get a Quote |
| PPAN-P2RY11 Knockout A-549 Cell Line | EDJ-KQ69148 | Human | 692312 | Details Get a Quote |
| P2RY11 Knockout HCT 116 Cell Line | EDJ-KQ71030 | Human | 5032 | Details Get a Quote |
| PPAN-P2RY11 Knockout HCT 116 Cell Line | EDJ-KQ77500 | Human | 692312 | Details Get a Quote |
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