P2RY10
Purinergic Receptor P2Y10
Gene Information Card
| Symbol | P2RY10 |
|---|---|
| Full Name | Purinergic Receptor P2Y10 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 27334 ncbi.nlm.nih.gov/gene/27334 |
| Ensembl ID | ENSG00000100031 |
| UniProt ID | O00398 |
| OMIM ID | 300529 |
| HGNC ID | 8542 |
| Aliases | P2Y10, P2Y-like receptor, P2RY10A |
Description
P2RY10 encodes a G protein-coupled receptor (GPCR) that belongs to the P2Y family of purinergic receptors. It is activated by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) and plays a role in immune cell signaling, particularly in B cells and T cells. The gene is located on the X chromosome and is implicated in immune regulation and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diffuse Large B-Cell Lymphoma | Altered expression may affect B-cell receptor signaling and tumor progression | COSMIC, ClinVar |
| Breast Cancer | Overexpression linked to poor prognosis; potential role in metastasis | NCBI Gene, COSMIC |
| Prostate Cancer | Differential expression observed; may influence androgen receptor signaling | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.7 | Low |
| Lung | 3.1 | Low |
| Breast | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (B-cell lymphoma) | 15.3 | High expression |
| Jurkat (T-cell leukemia) | 11.8 | Moderate expression |
| MCF7 (breast cancer) | 4.2 | Low expression |
| PC3 (prostate cancer) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown functional impact; rare variant |
| c.452G>A (p.Arg151His) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
| c.784_785insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated, non-functional receptor.
Gain of Function (GOF)
Not well documented; some missense variants may alter ligand binding.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • lysophosphatidic acid receptor activity |
| • sphingosine-1-phosphate receptor activity | • plasma membrane |
| • signal transduction | • immune response |
Pathways
• Lysophosphatidic acid (LPA) signaling
• Sphingosine 1-phosphate (S1P) signaling
• GPCR downstream signaling
Protein Summary
P2RY10 is a 7-transmembrane GPCR that binds LPA and S1P, mediating intracellular signaling via G proteins. It is predominantly expressed in lymphoid tissues and immune cells, where it modulates cell migration, proliferation, and survival. Altered expression and mutations are associated with hematologic malignancies and solid tumors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| P2RY10 Knockout HEK293 Cell Line | EDJ-KQ8776 | Human | 27334 | Details Get a Quote |
| P2RY10 Knockout HeLa Cell Line | EDJ-KQ56061 | Human | 27334 | Details Get a Quote |
| P2RY10 Knockout A-549 Cell Line | EDJ-KQ64544 | Human | 27334 | Details Get a Quote |
| P2RY10 Knockout HCT 116 Cell Line | EDJ-KQ73004 | Human | 27334 | Details Get a Quote |
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