OVOL3
OVO Like Zinc Finger 3
Gene Information Card
| Symbol | OVOL3 |
|---|---|
| Full Name | OVO Like Zinc Finger 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 728361 ncbi.nlm.nih.gov/gene/728361 |
| Ensembl ID | ENSG00000188352 |
| UniProt ID | Q6ZQN5 |
| OMIM ID | 619514 |
| HGNC ID | 26719 |
| Aliases | OVO3, ZNF339 |
Description
OVOL3 (OVO Like Zinc Finger 3) is a protein-coding gene that encodes a zinc finger transcription factor involved in epithelial differentiation and development. It belongs to the OVO-like family of proteins, which regulate gene expression during embryogenesis and tissue homeostasis. OVOL3 is expressed in various tissues and has been implicated in cancer biology, particularly in regulating cell proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | OVOL3 may act as a tumor suppressor or oncogene depending on context; altered expression linked to epithelial-mesenchymal transition. | PubMed (PMID: 31589630) |
| Colorectal cancer | Downregulation of OVOL3 associated with poor prognosis and increased invasion. | PubMed (PMID: 31589630) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Skin | 8.2 | Medium |
| Lung | 3.1 | Low |
| Breast | 2.5 | Low |
| Colon | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 4.0 | Moderate expression |
| MCF7 (breast cancer) | 2.1 | Low expression |
| HCT116 (colorectal cancer) | 1.5 | Low expression |
| HEK293 (embryonic kidney) | 0.8 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.1% | Unknown functional impact |
| c.205G>A (p.Gly69Arg) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Epithelial-to-mesenchymal transition (EMT) regulation
• Developmental biology (OVO-like family signaling)
Protein Summary
OVOL3 is a 339-amino acid zinc finger transcription factor that localizes to the nucleus. It contains three C2H2-type zinc finger domains that mediate sequence-specific DNA binding. The protein is involved in regulating gene expression during epithelial differentiation and may play a role in suppressing tumor progression by maintaining epithelial identity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OVOL3 Knockout HEK293 Cell Line | EDJ-KQ14650 | Human | 728361 | Details Get a Quote |
| OVOL3 Knockout HeLa Cell Line | EDJ-KQ60705 | Human | 728361 | Details Get a Quote |
| OVOL3 Knockout A-549 Cell Line | EDJ-KQ69177 | Human | 728361 | Details Get a Quote |
| OVOL3 Knockout HCT 116 Cell Line | EDJ-KQ77531 | Human | 728361 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
