OVGP1
Oviductal Glycoprotein 1
Gene Information Card
| Symbol | OVGP1 |
|---|---|
| Full Name | Oviductal Glycoprotein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.3 |
| NCBI Gene ID | 5016 ncbi.nlm.nih.gov/gene/5016 |
| Ensembl ID | ENSG00000185499 |
| UniProt ID | Q12889 |
| OMIM ID | 603578 |
| HGNC ID | 8526 |
| Aliases | MUC9, EGP, OGP, hOGP, mucin-9 |
Description
OVGP1 (Oviductal Glycoprotein 1) encodes a large, heavily glycosylated protein belonging to the mucin family. It is primarily expressed in the epithelial cells of the fallopian tube (oviduct) and is secreted into the lumen, where it binds to the zona pellucida of oocytes and spermatozoa. OVGP1 is thought to play a role in fertilization, early embryonic development, and immune modulation within the female reproductive tract. The protein is also known as mucin-9 (MUC9).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Female infertility (non-obstructive) | Reduced or absent OVGP1 expression may impair sperm-egg binding and fertilization | Limited; case-control studies show lower OVGP1 levels in infertile women |
| Endometriosis | Altered OVGP1 expression in ectopic endometrial tissue may affect tubal environment | Observational; immunohistochemistry studies |
| Tubal ectopic pregnancy | Dysregulated OVGP1 expression in fallopian tube may contribute to implantation outside uterus | Case-control; gene expression analysis |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Fallopian tube | 102.3 | High |
| Endometrium | 12.5 | Medium |
| Cervix, uterine | 8.1 | Low |
| Ovary | 3.2 | Low |
| Breast | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| OE-E6/E7 (fallopian tube epithelial) | 45.2 | High expression |
| HEC-1-A (endometrial) | 15.8 | Moderate expression |
| MCF7 (breast cancer) | 0.5 | Very low expression |
| HeLa (cervical cancer) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Premature stop; predicted loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Premature stop; predicted loss of function |
| c.890A>G (p.Asn297Ser) | Missense | 0.02% | Unknown; possibly benign |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (p.Arg412*, p.Trp189*) are predicted to cause loss of function via nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No gain-of-function mutations reported in OVGP1.
Dominant Negative (DN)
No dominant-negative mutations reported in OVGP1.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • extracellular space |
| • protein binding | • carbohydrate binding |
| • zona pellucida binding | • fertilization |
| • single fertilization | • female gamete generation |
| • cell adhesion |
Pathways
• Oocyte fertilization (Reactome: R-HSA-1187000)
• Glycoprotein metabolism (Reactome: R-HSA-446203)
Protein Summary
OVGP1 is a 684-amino-acid secreted mucin-like glycoprotein with a signal peptide, a large mucin domain rich in serine, threonine, and proline residues, and a C-terminal cysteine-rich domain. It is heavily O-glycosylated and N-glycosylated. The protein is synthesized by non-ciliated secretory cells of the fallopian tube epithelium and is released into the tubal fluid. OVGP1 binds to the zona pellucida of oocytes and to spermatozoa, facilitating sperm-egg recognition and fusion. It also exhibits immunomodulatory properties, potentially protecting gametes and embryos from maternal immune responses. Post-translational modifications are essential for its function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OVGP1 Knockout HEK293 Cell Line | EDJ-KQ5390 | Human | 5016 | Details Get a Quote |
| OVGP1 Knockout A-549 Cell Line | EDJ-KQ28526 | Human | 5016 | Details Get a Quote |
| OVGP1 Knockout HCT 116 Cell Line | EDJ-KQ28527 | Human | 5016 | Details Get a Quote |
| OVGP1 Knockout HeLa Cell Line | EDJ-KQ54064 | Human | 5016 | Details Get a Quote |
