OTULINL
OTU Deubiquitinase with Linear Linkage Specificity Like
Gene Information Card
| Symbol | OTULINL |
|---|---|
| Full Name | OTU deubiquitinase with linear linkage specificity like |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000254656 |
| UniProt ID | A0A1B0GTV6 |
| OMIM ID | 617056 |
| HGNC ID | 44268 |
| Aliases | OTULIN-like, C5orf56 |
Description
OTULINL (OTU deubiquitinase with linear linkage specificity like) is a protein-coding gene located on chromosome 5p15.33. It encodes a deubiquitinating enzyme that specifically cleaves linear (M1-linked) polyubiquitin chains, regulating NF-κB signaling and immune responses. OTULINL is paralogous to OTULIN and is involved in the negative regulation of linear ubiquitination-mediated signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not established | No evidence from OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • M1-linked polyubiquitin binding | • cysteine-type deubiquitinase activity |
| • negative regulation of NF-κB transcription factor activity |
Pathways
• Linear ubiquitination signaling
• NF-κB pathway
Protein Summary
OTULINL is a deubiquitinase that specifically cleaves linear (M1-linked) polyubiquitin chains. It shares structural similarity with OTULIN and is thought to regulate immune signaling by removing linear ubiquitin chains from substrates, thereby dampening NF-κB activation. Its expression is very low or absent in most tissues and cell lines tested.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OTULINL Knockout HEK293 Cell Line | EDJ-KQ11436 | Human | 54491 | Details Get a Quote |
| OTULINL Knockout A-549 Cell Line | EDJ-KQ39697 | Human | 54491 | Details Get a Quote |
| OTULINL Knockout HCT 116 Cell Line | EDJ-KQ39698 | Human | 54491 | Details Get a Quote |
| OTULINL Knockout HeLa Cell Line | EDJ-KQ39699 | Human | 54491 | Details Get a Quote |
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