OSM (Oncostatin M) Gene
Cytokine Gene in Immune Regulation and Inflammation
Gene Information Card
| Symbol | OSM |
|---|---|
| Full Name | Oncostatin M |
| Gene Type | protein-coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 5008 ncbi.nlm.nih.gov/gene/5008 |
| Ensembl ID | ENSG00000128272 |
| UniProt ID | P13725 |
| OMIM ID | 165095 |
| HGNC ID | 8506 |
| Aliases | OSM |
Description
The OSM gene encodes oncostatin M, a pleiotropic cytokine of the interleukin-6 family. It is involved in cell growth, differentiation, inflammation, and hematopoiesis. OSM signals through the gp130 receptor complex and plays roles in liver development, bone formation, and immune responses. Dysregulation is linked to inflammatory diseases and cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | OSM promotes synovial inflammation and joint destruction via STAT3 activation | PMID: 10880460 |
| Colorectal Cancer | OSM overexpression correlates with tumor progression and poor prognosis | PMID: 25691885 |
| Inflammatory Bowel Disease | OSM is a key driver of intestinal inflammation and fibrosis | PMID: 28263392 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 0.4 | Low |
| Lung | 0.3 | Low |
| Spleen | 0.2 | Low |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 0.5 | Monocyte line, induced by LPS |
| HUVEC | 0.2 | Endothelial cells, low baseline |
| A549 | 0.1 | Lung carcinoma, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Likely benign |
| c.100C>T | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity | • growth factor activity |
| • interleukin-6 receptor binding | • extracellular space |
| • positive regulation of cell proliferation | • positive regulation of JAK-STAT cascade |
Pathways
• IL-6 family signaling
• JAK-STAT signaling pathway
• Cytokine-cytokine receptor interaction
Protein Summary
Oncostatin M is a 28 kDa glycoprotein cytokine. It binds to the OSM receptor (OSMR) and gp130, activating JAK/STAT, MAPK, and PI3K pathways. It regulates inflammation, hematopoiesis, and tissue remodeling. Elevated levels are observed in inflammatory diseases and certain cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OSMR & IL6ST Overexpression U2OS Stable Cell Line | EDJ-GQ82 | Human | 9180 & 3572 | Details Get a Quote |
| OSM Knockout HEK293 Cell Line | EDJ-KQ512 | Human | 5008 | Details Get a Quote |
| OSMR Knockout HEK293 Cell Line | EDJ-KQ514 | Human | 9180 | Details Get a Quote |
| OSMR Knockout A-549 Cell Line | EDJ-KQ18013 | Human | 9180 | Details Get a Quote |
| OSMR Knockout HCT 116 Cell Line | EDJ-KQ18840 | Human | 9180 | Details Get a Quote |
| OSMR Knockout HeLa Cell Line | EDJ-KQ18841 | Human | 9180 | Details Get a Quote |
| OSM Knockout HeLa Cell Line | EDJ-KQ54060 | Human | 5008 | Details Get a Quote |
| OSM Knockout A-549 Cell Line | EDJ-KQ62548 | Human | 5008 | Details Get a Quote |
| OSM Knockout HCT 116 Cell Line | EDJ-KQ71020 | Human | 5008 | Details Get a Quote |
