OR7G3: Olfactory Receptor Family 7 Subfamily G Member 3
A G protein-coupled olfactory receptor involved in odorant detection and sensory transduction.
Gene Information Card
| Symbol | OR7G3 |
|---|---|
| Full Name | Olfactory Receptor Family 7 Subfamily G Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.12 |
| NCBI Gene ID | 390893 ncbi.nlm.nih.gov/gene/390893 |
| Ensembl ID | ENSG00000188000 |
| UniProt ID | Q8NG95 |
| OMIM ID | Not available |
| HGNC ID | 15388 |
| Aliases | OR19-18, OR7G3P, OR7G3Q |
Description
OR7G3 encodes an olfactory receptor that belongs to the G protein-coupled receptor (GPCR) superfamily. These receptors are primarily expressed in the olfactory epithelium and are involved in the detection of odorants, initiating a signaling cascade that leads to the perception of smell. The gene is located on chromosome 19p13.12 and is part of a large family of olfactory receptor genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from curated databases |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not expressed |
| Brain | 0.0 | Not expressed |
| Lung | 0.0 | Not expressed |
| Liver | 0.0 | Not expressed |
| Kidney | 0.0 | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data | N/A | No data available in curated sources |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | No clinically significant variants reported |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • signal transduction |
| • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR7G3 is a 312-amino acid protein with seven transmembrane domains, characteristic of GPCRs. It is predicted to localize to the plasma membrane and function in odorant binding and signal transduction. No structural or functional studies have been published, and its specific ligands remain unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR7G3 Knockout HEK293 Cell Line | EDJ-KQ8567 | Human | 390883 | Details Get a Quote |
| OR7G3 Knockout HeLa Cell Line | EDJ-KQ60195 | Human | 390883 | Details Get a Quote |
| OR7G3 Knockout A-549 Cell Line | EDJ-KQ68657 | Human | 390883 | Details Get a Quote |
| OR7G3 Knockout HCT 116 Cell Line | EDJ-KQ77024 | Human | 390883 | Details Get a Quote |
