OR6K6
Olfactory Receptor Family 6 Subfamily K Member 6
Gene Information Card
| Symbol | OR6K6 |
|---|---|
| Full Name | Olfactory Receptor Family 6 Subfamily K Member 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q23.2 |
| NCBI Gene ID | 219431 ncbi.nlm.nih.gov/gene/219431 |
| Ensembl ID | ENSG00000184933 |
| UniProt ID | Q8NGX2 |
| OMIM ID | 618575 |
| HGNC ID | 15378 |
| Aliases | OR6K6P, OR6K6Q |
Description
OR6K6 (Olfactory Receptor Family 6 Subfamily K Member 6) is a protein-coding gene that belongs to the olfactory receptor family, a large group of G protein-coupled receptors (GPCRs) responsible for detecting odorants. The gene is located on chromosome 1q23.2 and is expressed in the olfactory epithelium. Olfactory receptors interact with odorant molecules to initiate a neuronal response that triggers the perception of smell. OR6K6 is considered an intact, functional receptor based on sequence analysis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | Not available | Not available |
| Testis | Not available | Not available |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data available | Not available | Not available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR6K6 encodes a 312-amino acid protein that is a member of the olfactory receptor family. These receptors are characterized by a seven-transmembrane domain structure typical of GPCRs. The protein is predicted to localize to the plasma membrane and function in odorant recognition and signal transduction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR6K6 Knockout HEK293 Cell Line | EDJ-KQ8398 | Human | 128371 | Details Get a Quote |
| OR6K6 Knockout HeLa Cell Line | EDJ-KQ58236 | Human | 128371 | Details Get a Quote |
| OR6K6 Knockout A-549 Cell Line | EDJ-KQ66724 | Human | 128371 | Details Get a Quote |
| OR6K6 Knockout HCT 116 Cell Line | EDJ-KQ75133 | Human | 128371 | Details Get a Quote |
