OR6A2
Olfactory Receptor Family 6 Subfamily A Member 2
Gene Information Card
| Symbol | OR6A2 |
|---|---|
| Full Name | Olfactory Receptor Family 6 Subfamily A Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 8590 ncbi.nlm.nih.gov/gene/8590 |
| Ensembl ID | ENSG00000184933 |
| UniProt ID | O95222 |
| OMIM ID | 608495 |
| HGNC ID | 8471 |
| Aliases | OR6A1, OR11-55, OR6A2P |
Description
OR6A2 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family. These receptors are expressed in olfactory sensory neurons and detect odorants. Polymorphisms in OR6A2 are associated with individual differences in the perception of cilantro (coriander) aroma, particularly the soapy or pungent note.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cilantro taste aversion | Polymorphisms (e.g., rs72921001) alter receptor sensitivity to aldehydes in cilantro | ClinVar, GWAS studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 0.0 | Not detected (nTPM) in standard GTEx tissues; expressed in olfactory epithelium |
| Nasal epithelium | 0.0 | Low/undetectable in bulk RNA-seq; enriched in olfactory neurons |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Used in heterologous expression assays for functional studies |
| Olfactory sensory neurons | N/A | Cell-specific expression; not captured in standard cell lines |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs72921001 | SNV | 0.15 (C allele in Europeans) | Alters receptor response to (E)-2-decenal, a key cilantro aldehyde |
Mutation functional classification
Loss of Function (LOF)
rs72921001 C allele reduces receptor activation by cilantro aldehydes
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR ligand binding (Reactome: R-HSA-500792)
Protein Summary
OR6A2 is a 312-amino acid transmembrane protein with seven helical domains typical of olfactory GPCRs. It binds volatile aldehydes, such as (E)-2-decenal, contributing to the perception of cilantro's characteristic flavor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR6A2 Knockout HEK293 Cell Line | EDJ-KQ6295 | Human | 8590 | Details Get a Quote |
| OR6A2 Knockout HeLa Cell Line | EDJ-KQ54948 | Human | 8590 | Details Get a Quote |
| OR6A2 Knockout A-549 Cell Line | EDJ-KQ63434 | Human | 8590 | Details Get a Quote |
| OR6A2 Knockout HCT 116 Cell Line | EDJ-KQ71900 | Human | 8590 | Details Get a Quote |
