OR5P3: Olfactory Receptor Family 5 Subfamily P Member 3
A chemosensory GPCR involved in odorant detection and potential roles in extra-nasal tissues.
Gene Information Card
| Symbol | OR5P3 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily P Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 120066 ncbi.nlm.nih.gov/gene/120066 |
| Ensembl ID | ENSG00000172199 |
| UniProt ID | Q8WZ92 |
| OMIM ID | 618448 |
| HGNC ID | 14796 |
| Aliases | OR5P3P, OR5P3Q, OR11-103 |
Description
OR5P3 encodes a member of the olfactory receptor (OR) family, a large class of G protein-coupled receptors (GPCRs) that mediate odorant detection in the olfactory epithelium. OR5P3 is also expressed in non-olfactory tissues, suggesting potential roles in chemosensation beyond the nose. The gene is located on chromosome 11p15.4 within a cluster of olfactory receptor genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Prostate | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No detectable expression |
| HeLa | 0.0 | No detectable expression |
| K562 | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling
Protein Summary
OR5P3 is a 312-amino acid transmembrane protein belonging to the rhodopsin-like GPCR family. It contains seven transmembrane domains typical of olfactory receptors. The protein is predicted to localize to the plasma membrane and function in odorant binding and signal transduction via G protein activation. No experimentally determined structure is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5P3 Knockout HEK293 Cell Line | EDJ-KQ7654 | Human | 120066 | Details Get a Quote |
| OR5P3 Knockout HeLa Cell Line | EDJ-KQ58057 | Human | 120066 | Details Get a Quote |
| OR5P3 Knockout A-549 Cell Line | EDJ-KQ66545 | Human | 120066 | Details Get a Quote |
| OR5P3 Knockout HCT 116 Cell Line | EDJ-KQ74960 | Human | 120066 | Details Get a Quote |
