OR5P2: Olfactory Receptor Family 5 Subfamily P Member 2
A chemosensory GPCR involved in odorant detection and potential roles in extra-nasal tissues.
Gene Information Card
| Symbol | OR5P2 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily P Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 120065 ncbi.nlm.nih.gov/gene/120065 |
| Ensembl ID | ENSG00000196352 |
| UniProt ID | Q8WZ92 |
| OMIM ID | 618377 |
| HGNC ID | 14797 |
| Aliases | OR5P2P, OR5P2Q, OR11-102 |
Description
OR5P2 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) superfamily. These receptors are primarily expressed in olfactory sensory neurons and mediate odorant detection. OR5P2 may also have roles in extra-nasal tissues, including potential involvement in cancer and cell signaling. The gene is located on chromosome 11p15.4 and is part of the large olfactory receptor gene family.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No detectable expression |
| HeLa | 0.0 | No detectable expression |
| A549 | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR5P2 is a 312-amino acid transmembrane protein with seven helical domains characteristic of GPCRs. It is predicted to localize to the plasma membrane and function in odorant binding and signal transduction via G proteins. No 3D structure has been experimentally determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5P2 Knockout HEK293 Cell Line | EDJ-KQ7653 | Human | 120065 | Details Get a Quote |
| OR5P2 Knockout HeLa Cell Line | EDJ-KQ58056 | Human | 120065 | Details Get a Quote |
| OR5P2 Knockout A-549 Cell Line | EDJ-KQ66544 | Human | 120065 | Details Get a Quote |
| OR5P2 Knockout HCT 116 Cell Line | EDJ-KQ74959 | Human | 120065 | Details Get a Quote |
