OR5F1
Olfactory Receptor Family 5 Subfamily F Member 1
Gene Information Card
| Symbol | OR5F1 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily F Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 81448 ncbi.nlm.nih.gov/gene/81448 |
| Ensembl ID | ENSG00000172137 |
| UniProt ID | Q8NH75 |
| OMIM ID | 618416 |
| HGNC ID | 14798 |
| Aliases | OR5F1P, OR5F1Q, OR5F1R |
Description
OR5F1 (Olfactory Receptor Family 5 Subfamily F Member 1) is a protein-coding gene that belongs to the olfactory receptor superfamily. These receptors are G protein-coupled receptors (GPCRs) responsible for detecting odorants in the nasal epithelium. OR5F1 is expressed in olfactory sensory neurons and is involved in the perception of smell. The gene is located on chromosome 11q12.1 and is part of a large cluster of olfactory receptor genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease association | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR signaling
Protein Summary
OR5F1 encodes a 312-amino acid protein that is a member of the olfactory receptor family. The protein is a seven-transmembrane GPCR localized to the plasma membrane of olfactory sensory neurons. It binds odorant molecules and activates a G protein signaling cascade leading to neuronal depolarization and smell perception.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5F1 Knockout HEK293 Cell Line | EDJ-KQ6296 | Human | 338674 | Details Get a Quote |
| OR5F1 Knockout HeLa Cell Line | EDJ-KQ59619 | Human | 338674 | Details Get a Quote |
| OR5F1 Knockout A-549 Cell Line | EDJ-KQ68085 | Human | 338674 | Details Get a Quote |
| OR5F1 Knockout HCT 116 Cell Line | EDJ-KQ76460 | Human | 338674 | Details Get a Quote |
