OR5C1
Olfactory Receptor Family 5 Subfamily C Member 1
Gene Information Card
| Symbol | OR5C1 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily C Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.2 |
| NCBI Gene ID | 26600 ncbi.nlm.nih.gov/gene/26600 |
| Ensembl ID | ENSG00000197918 |
| UniProt ID | Q8NGF9 |
| OMIM ID | 611521 |
| HGNC ID | 8352 |
| Aliases | OR5C1P, OR5C1Q, OR11-106 |
Description
OR5C1 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family. These receptors are expressed in the olfactory epithelium and mediate the detection of odorants, initiating a neuronal response that triggers the perception of smell. OR5C1 is part of the large olfactory receptor gene family, which is the largest in the genome.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • signal transduction |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR5C1 is a 312-amino acid transmembrane protein with seven helical domains characteristic of GPCRs. It is predicted to localize to the plasma membrane of olfactory sensory neurons and bind odorant molecules, activating a G protein signaling cascade that leads to neuronal depolarization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5C1 Knockout HEK293 Cell Line | EDJ-KQ8580 | Human | 392391 | Details Get a Quote |
| OR5C1 Knockout HeLa Cell Line | EDJ-KQ60231 | Human | 392391 | Details Get a Quote |
| OR5C1 Knockout A-549 Cell Line | EDJ-KQ68693 | Human | 392391 | Details Get a Quote |
| OR5C1 Knockout HCT 116 Cell Line | EDJ-KQ77060 | Human | 392391 | Details Get a Quote |
