OR5AR1
Olfactory Receptor Family 5 Subfamily AR Member 1
Gene Information Card
| Symbol | OR5AR1 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily AR Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 81396 ncbi.nlm.nih.gov/gene/81396 |
| Ensembl ID | ENSG00000181894 |
| UniProt ID | Q8NGX6 |
| OMIM ID | not available |
| HGNC ID | 14798 |
| Aliases | OR5AR1P, OR5AR1Q |
Description
OR5AR1 is a protein-coding gene that belongs to the olfactory receptor family, a large group of G protein-coupled receptors (GPCRs) responsible for detecting odorants in the nasal epithelium. The encoded protein is involved in sensory perception of smell, transducing chemical signals from the environment into neuronal responses. OR5AR1 is located on chromosome 11q12.1 and is expressed in various tissues, including the olfactory epithelium and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 0.5 | Low |
| Testis | 0.3 | Low |
| Brain | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low expression |
| HepG2 | 0.1 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR5AR1 encodes a 312-amino acid protein with seven transmembrane domains characteristic of GPCRs. It functions as an odorant receptor, binding volatile chemicals and activating intracellular signaling cascades via G proteins. The protein is localized to the plasma membrane of olfactory sensory neurons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5AR1 Knockout HEK293 Cell Line | EDJ-KQ8205 | Human | 219493 | Details Get a Quote |
| OR5AR1 Knockout HeLa Cell Line | EDJ-KQ59084 | Human | 219493 | Details Get a Quote |
| OR5AR1 Knockout A-549 Cell Line | EDJ-KQ67560 | Human | 219493 | Details Get a Quote |
| OR5AR1 Knockout HCT 116 Cell Line | EDJ-KQ75954 | Human | 219493 | Details Get a Quote |
