OR5A2
Olfactory Receptor Family 5 Subfamily A Member 2
Gene Information Card
| Symbol | OR5A2 |
|---|---|
| Full Name | Olfactory Receptor Family 5 Subfamily A Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 390155 ncbi.nlm.nih.gov/gene/390155 |
| Ensembl ID | ENSG00000172420 |
| UniProt ID | Q8NGI9 |
| OMIM ID | 618514 |
| HGNC ID | 15287 |
| Aliases | OR5A2P, OR5A2Q, OR11-248 |
Description
OR5A2 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) superfamily. These receptors are primarily expressed in the olfactory epithelium and mediate the detection of odorants. OR5A2 is a member of the olfactory receptor family 5, subfamily A, and is located on chromosome 11q12.1. The gene is intronless and is considered a canonical olfactory receptor gene.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data available | N/A | No nTPM values reported in GTEx or Human Protein Atlas |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function variants documented in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function variants documented.
Dominant Negative (DN)
No dominant-negative variants documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR ligand binding (Reactome: R-HSA-500792)
Protein Summary
OR5A2 is a 312-amino acid olfactory receptor protein with seven transmembrane domains characteristic of GPCRs. It is predicted to localize to the plasma membrane of olfactory sensory neurons and function in odorant recognition. No functional studies or ligand specificity have been experimentally determined for this receptor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR5A2 Knockout HEK293 Cell Line | EDJ-KQ8479 | Human | 219981 | Details Get a Quote |
| OR5A2 Knockout HeLa Cell Line | EDJ-KQ59123 | Human | 219981 | Details Get a Quote |
| OR5A2 Knockout A-549 Cell Line | EDJ-KQ67597 | Human | 219981 | Details Get a Quote |
| OR5A2 Knockout HCT 116 Cell Line | EDJ-KQ75988 | Human | 219981 | Details Get a Quote |
