OR52L1 Olfactory Receptor Family 52 Subfamily L Member 1
A chemosensory GPCR involved in odorant detection
Gene Information Card
| Symbol | OR52L1 |
|---|---|
| Full Name | Olfactory Receptor Family 52 Subfamily L Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 338751 ncbi.nlm.nih.gov/gene/338751 |
| Ensembl ID | ENSG00000205469 |
| UniProt ID | Q8NGI7 |
| OMIM ID | 618425 |
| HGNC ID | 15203 |
| Aliases | OR11-104, OR52L1P |
Description
OR52L1 encodes a member of the olfactory receptor family, a diverse group of G-protein-coupled receptors (GPCRs) that detect odorants in the nasal epithelium. The protein is localized to the cilia of olfactory sensory neurons and initiates a signal transduction cascade upon ligand binding. OR52L1 is considered an intact, functional receptor based on genomic and transcriptomic evidence.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
| • integral component of membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR52L1 is a 312-amino acid olfactory receptor belonging to the rhodopsin-like GPCR superfamily. It contains seven transmembrane domains and is predicted to bind volatile odorants. The protein is encoded by a single-exon gene and is expressed primarily in olfactory tissues, though transcript levels are low in standard RNA-seq datasets.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR52L1 Knockout HEK293 Cell Line | EDJ-KQ14633 | Human | 338751 | Details Get a Quote |
| OR52L1 Knockout HeLa Cell Line | EDJ-KQ59621 | Human | 338751 | Details Get a Quote |
| OR52L1 Knockout A-549 Cell Line | EDJ-KQ68087 | Human | 338751 | Details Get a Quote |
| OR52L1 Knockout HCT 116 Cell Line | EDJ-KQ76462 | Human | 338751 | Details Get a Quote |
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