OR51S1
Olfactory Receptor Family 51 Subfamily S Member 1
Gene Information Card
| Symbol | OR51S1 |
|---|---|
| Full Name | Olfactory Receptor Family 51 Subfamily S Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 119694 ncbi.nlm.nih.gov/gene/119694 |
| Ensembl ID | ENSG00000254709 |
| UniProt ID | Q8NGI9 |
| OMIM ID | 614575 |
| HGNC ID | 15212 |
| Aliases | OR51S1P, OR11-29 |
Description
OR51S1 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family. These receptors are expressed in the olfactory epithelium and mediate the detection of odorants. The gene is located on chromosome 11p15.4 within a cluster of olfactory receptor genes. OR51S1 is considered an intact protein-coding gene based on reference genome annotations.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR51S1 is a 312-amino acid olfactory receptor protein with seven transmembrane domains, characteristic of GPCRs. It is predicted to localize to the plasma membrane and function in odorant recognition. No functional studies or crystal structures are currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR51S1 Knockout HEK293 Cell Line | EDJ-KQ7645 | Human | 119692 | Details Get a Quote |
| OR51S1 Knockout HeLa Cell Line | EDJ-KQ58047 | Human | 119692 | Details Get a Quote |
| OR51S1 Knockout A-549 Cell Line | EDJ-KQ66535 | Human | 119692 | Details Get a Quote |
| OR51S1 Knockout HCT 116 Cell Line | EDJ-KQ74950 | Human | 119692 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
