OR51E2
Olfactory Receptor Family 51 Subfamily E Member 2
Gene Information Card
| Symbol | OR51E2 |
|---|---|
| Full Name | Olfactory Receptor Family 51 Subfamily E Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 81285 ncbi.nlm.nih.gov/gene/81285 |
| Ensembl ID | ENSG00000183309 |
| UniProt ID | Q9H255 |
| OMIM ID | 611267 |
| HGNC ID | 15193 |
| Aliases | PSGR, OR51E2P, OR51E2Q |
Description
OR51E2 encodes a G-protein coupled receptor (GPCR) belonging to the olfactory receptor superfamily. It is also known as prostate-specific G-protein coupled receptor (PSGR) due to its high expression in prostate tissue. The receptor is activated by odorants such as beta-ionone and has been implicated in prostate cancer cell proliferation and migration. OR51E2 is considered a potential biomarker and therapeutic target in prostate cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Overexpression of OR51E2 in prostate epithelium; activation by beta-ionone promotes cell proliferation and migration via MAPK/ERK signaling | PMID: 16959961, PMID: 23251476 |
| Colorectal Cancer | Aberrant OR51E2 expression detected in colorectal tumors; role in tumorigenesis under investigation | PMID: 24667604 |
| Breast Cancer | OR51E2 expression reported in breast cancer cell lines; functional significance unclear | PMID: 21804535 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 27.8 | High |
| Colon | 4.2 | Low |
| Breast | 1.5 | Low |
| Testis | 0.8 | Not detected |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 32.1 | High expression |
| PC-3 (prostate cancer) | 18.5 | Moderate expression |
| DU145 (prostate cancer) | 15.0 | Moderate expression |
| MCF-7 (breast cancer) | 2.3 | Low expression |
| HT-29 (colorectal cancer) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | missense | <0.1% in COSMIC | Unknown functional effect |
| c.200T>C (p.Leu67Pro) | missense | <0.1% in COSMIC | Unknown functional effect |
| c.350A>G (p.Asn117Ser) | missense | <0.1% in COSMIC | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No validated loss-of-function mutations reported in OR51E2.
Gain of Function (GOF)
No validated gain-of-function mutations reported in OR51E2.
Dominant Negative (DN)
No dominant-negative mutations reported for OR51E2.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • signal transduction |
| • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
OR51E2 is a 320-amino acid transmembrane protein belonging to the rhodopsin-like GPCR family. It contains seven transmembrane domains and is localized to the plasma membrane. The receptor binds odorants such as beta-ionone and activates intracellular signaling cascades including MAPK/ERK and cAMP pathways. Its expression is highly enriched in prostate epithelium, where it may regulate cell growth and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR51E2 Knockout HEK293 Cell Line | EDJ-KQ9658 | Human | 81285 | Details Get a Quote |
| OR51E2 Knockout HeLa Cell Line | EDJ-KQ57373 | Human | 81285 | Details Get a Quote |
| OR51E2 Knockout A-549 Cell Line | EDJ-KQ65879 | Human | 81285 | Details Get a Quote |
| OR51E2 Knockout HCT 116 Cell Line | EDJ-KQ74306 | Human | 81285 | Details Get a Quote |
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