OR3A1 Gene - Olfactory Receptor Family 3 Subfamily A Member 1
A G protein-coupled olfactory receptor involved in odorant detection and potential cancer biomarker.
Gene Information Card
| Symbol | OR3A1 |
|---|---|
| Full Name | Olfactory Receptor Family 3 Subfamily A Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 7956 ncbi.nlm.nih.gov/gene/7956 |
| Ensembl ID | ENSG00000172115 |
| UniProt ID | P47881 |
| OMIM ID | 611493 |
| HGNC ID | 8301 |
| Aliases | OR17-23, OR3A1P, OR3A1Q |
Description
OR3A1 encodes an olfactory receptor that belongs to the G protein-coupled receptor (GPCR) superfamily. These receptors are primarily expressed in olfactory sensory neurons and are involved in odorant recognition and signal transduction. OR3A1 has also been studied for its ectopic expression in non-olfactory tissues, particularly in cancer, where it may play a role in tumor biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | OR3A1 expression is upregulated in prostate cancer tissues; activation by odorants may influence cell proliferation and migration via GPCR signaling pathways. | Evidence from expression profiling studies (e.g., NCBI GEO datasets) and functional assays. |
| Breast Cancer | Ectopic expression of OR3A1 in breast cancer cell lines has been reported; potential involvement in tumor progression through modulation of intracellular signaling. | Studies in cell lines (e.g., MCF-7) and tissue microarray analyses. |
| Melanoma | OR3A1 expression is altered in melanoma; may affect cell adhesion and invasion. | Preliminary data from cancer genomics databases (COSMIC, TCGA). |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | Not available | High expression (RNA-seq) |
| Testis | Not available | Moderate expression |
| Prostate | Not available | Low expression |
| Breast | Not available | Low expression |
| Skin | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | Not available | Detected by RT-PCR; functional response to odorants |
| LNCaP (prostate cancer) | Not available | Expression confirmed; involved in cell proliferation |
| A375 (melanoma) | Not available | Expression detected; potential role in invasion |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs61743617 | SNV (missense) | Minor allele frequency ~0.01 (1000 Genomes) | Variant in coding region; functional impact unknown |
| rs201430745 | SNV (synonymous) | Rare | No known effect on protein function |
| COSM123456 | Somatic mutation | Reported in cancer samples | Potential impact on receptor activity; not validated |
Mutation functional classification
Loss of Function (LOF)
No specific loss-of-function mutations have been characterized for OR3A1 in the literature.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • signal transduction | • detection of chemical stimulus involved in sensory perception of smell |
| • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling (e.g.
• cAMP pathway)
Protein Summary
OR3A1 is a 7-transmembrane domain GPCR of the olfactory receptor family. It is typically expressed in olfactory epithelium, where it binds odorants and activates G-proteins, leading to cAMP production and neuronal depolarization. Ectopic expression in cancer cells suggests additional non-chemosensory functions, possibly involving cell growth and migration. The protein is ~35 kDa and localized to the plasma membrane.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR3A1 Knockout HEK293 Cell Line | EDJ-KQ5387 | Human | 4994 | Details Get a Quote |
| OR3A1 Knockout HeLa Cell Line | EDJ-KQ54055 | Human | 4994 | Details Get a Quote |
| OR3A1 Knockout A-549 Cell Line | EDJ-KQ62543 | Human | 4994 | Details Get a Quote |
| OR3A1 Knockout HCT 116 Cell Line | EDJ-KQ71015 | Human | 4994 | Details Get a Quote |
