OR2V2 Gene: Olfactory Receptor Family 2 Subfamily V Member 2
A comprehensive guide to OR2V2, including genomic information, expression, and disease associations.
Gene Information Card
| Symbol | OR2V2 |
|---|---|
| Full Name | Olfactory Receptor Family 2 Subfamily V Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 81271 ncbi.nlm.nih.gov/gene/81271 |
| Ensembl ID | ENSG00000196873 |
| UniProt ID | Q8NG97 |
| OMIM ID | 612376 |
| HGNC ID | 14790 |
| Aliases | OR2V2P, OR2V2Q, OR5.3B4 |
Description
OR2V2 is a protein-coding gene that encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) superfamily. Olfactory receptors are primarily expressed in the olfactory epithelium and are responsible for detecting odorants, initiating a neuronal response that triggers the perception of smell. The OR2V2 gene is located on chromosome 5 at band q35.3 and is part of the large olfactory receptor gene family. While its specific odorant ligands are not fully characterized, it is presumed to function in odor detection. The gene is also noted for its expression in various tissues, suggesting potential non-olfactory roles.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Disease | Mechanism | Evidence |
| No specific disease association | Not established | No curated disease associations found in OMIM, ClinVar, or COSMIC. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tissue | nTPM | Level |
| Testis | 0.8 | Low |
| Skin | 0.5 | Low |
| Lung | 0.3 | Low |
| Other tissues | Not detected | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cell Line | nTPM | Notes |
| No data available | N/A | Expression in cell lines not reported in the Human Protein Atlas. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Variant | Type | Frequency | Effect |
| No curated variants | N/A | N/A | No variants reported in ClinVar or COSMIC for OR2V2. |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been characterized for OR2V2.
Gain of Function (GOF)
No gain-of-function mutations have been characterized for OR2V2.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for OR2V2.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • integral component of membrane |
| • signal transduction | • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory signaling pathway (Reactome: R-HSA-381753)
Protein Summary
The OR2V2 protein is a seven-transmembrane G protein-coupled receptor. It is predicted to localize to the plasma membrane and function in odorant detection. The protein is 312 amino acids long and has a molecular weight of approximately 35 kDa. Structural studies suggest a typical GPCR fold with an extracellular N-terminus and intracellular C-terminus. The protein is expressed at low levels in a few tissues, but its functional significance outside the olfactory system remains unclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR2V2 Knockout HEK293 Cell Line | EDJ-KQ2771 | Human | 285659 | Details Get a Quote |
| OR2V2 Knockout HeLa Cell Line | EDJ-KQ59526 | Human | 285659 | Details Get a Quote |
| OR2V2 Knockout A-549 Cell Line | EDJ-KQ67995 | Human | 285659 | Details Get a Quote |
| OR2V2 Knockout HCT 116 Cell Line | EDJ-KQ76373 | Human | 285659 | Details Get a Quote |
