OR2V1 Gene: Function, Location, and Expression | Biomedical Database

OR2V1 (Olfactory Receptor Family 2 Subfamily V Member 1) is a protein-coding gene located on the long arm of chromosome 5 (5q35.3). It encodes a member of the G-protein coupled receptor (GPCR) family, specifically belonging to the olfactory receptor superfamily. These receptors are primarily expressed in the olfactory epithelium and are responsible for the detection of odorants, initiating a signaling cascade that leads to the perception of smell. The protein is characterized by a 7-transmembrane domain structure typical of GPCRs. While its primary role is in olfaction, olfactory receptors have also been found in other tissues, suggesting potential non-olfactory functions. The gene is intronless, a common feature among olfactory receptor genes.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Olfactory Signaling Pathway (Reactome: R-HSA-381753)

The OR2V1 protein is a typical olfactory receptor, a class A (rhodopsin-like) G-protein coupled receptor. It is predicted to have seven transmembrane alpha-helices, an extracellular N-terminus, and an intracellular C-terminus. The protein is involved in the detection of odorant molecules, which bind to the receptor and activate a G-protein (Golf), leading to the activation of adenylyl cyclase and an increase in cAMP. This triggers a signaling cascade that ultimately results in an action potential in the olfactory neuron. The specific odorant ligand for OR2V1 has not been identified. The protein is predicted to be localized to the plasma membrane of olfactory cilia.