OR2M7: Olfactory Receptor Family 2 Subfamily M Member 7
A G protein-coupled olfactory receptor involved in odorant detection, with potential roles in chemosensory signaling and disease association studies.
Gene Information Card
| Symbol | OR2M7 |
|---|---|
| Full Name | Olfactory Receptor Family 2 Subfamily M Member 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q44 |
| NCBI Gene ID | 127062 ncbi.nlm.nih.gov/gene/127062 |
| Ensembl ID | ENSG00000197859 |
| UniProt ID | Q8NG83 |
| OMIM ID | Not available |
| HGNC ID | HGNC:19582 |
| Aliases | OR2M7P, OR2M7Q |
Description
OR2M7 encodes an olfactory receptor protein belonging to the G protein-coupled receptor (GPCR) family. These receptors are primarily expressed in the olfactory epithelium and are involved in the detection of odorants, initiating a signaling cascade that leads to the perception of smell. The gene is located on chromosome 1q44 and is part of the large olfactory receptor gene family. While its specific odorant ligands are not fully characterized, OR2M7 is expressed in various tissues, suggesting potential non-olfactory functions. Genetic variations in OR2M7 have been studied for associations with certain diseases, though conclusive evidence is limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Rhinosinusitis | Altered olfactory receptor expression may affect odorant detection and contribute to olfactory dysfunction. | Expression studies show differential regulation in nasal tissues; however, direct causal evidence is lacking. |
| Prostate Cancer | Ectopic expression of olfactory receptors in non-olfactory tissues may influence cell proliferation and migration. | In silico analysis suggests OR2M7 is overexpressed in prostate cancer tissues, but functional studies are needed. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Prostate | 0.5 | Low |
| Lung | 0.3 | Low |
| Brain | 0.2 | Low |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low expression; used for heterologous expression studies |
| HeLa | 0.1 | Minimal expression |
| A549 | 0.3 | Low expression; lung carcinoma cell line |
| PC3 | 0.6 | Moderate expression; prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs201253971 | Missense (p.Arg153His) | 0.1% (global) | Potential alteration in ligand binding; functional impact unknown |
| rs148613699 | Missense (p.Val220Met) | 0.05% (global) | May affect receptor stability; no clinical significance reported |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations have been reported for OR2M7 in public databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations have been reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • integral component of membrane |
| • signal transduction | • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory signaling pathway (Reactome: R-HSA-381753)
• GPCR downstream signaling (Reactome: R-HSA-372790)
Protein Summary
OR2M7 is a 312-amino acid protein with seven transmembrane domains, characteristic of GPCRs. It is predicted to localize to the plasma membrane and function in odorant recognition. The protein shares high sequence similarity with other olfactory receptors, particularly in the transmembrane regions. Structural studies are limited, but homology modeling suggests a typical GPCR fold with an extracellular ligand-binding pocket. Post-translational modifications, such as glycosylation, may occur but are not experimentally confirmed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR2M7 Knockout HEK293 Cell Line | EDJ-KQ14575 | Human | 391196 | Details Get a Quote |
| OR2M7 Knockout HeLa Cell Line | EDJ-KQ60216 | Human | 391196 | Details Get a Quote |
| OR2M7 Knockout A-549 Cell Line | EDJ-KQ68678 | Human | 391196 | Details Get a Quote |
| OR2M7 Knockout HCT 116 Cell Line | EDJ-KQ77045 | Human | 391196 | Details Get a Quote |
