OR2J3
Olfactory Receptor Family 2 Subfamily J Member 3
Gene Information Card
| Symbol | OR2J3 |
|---|---|
| Full Name | Olfactory Receptor Family 2 Subfamily J Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 442184 ncbi.nlm.nih.gov/gene/442184 |
| Ensembl ID | ENSG00000196139 |
| UniProt ID | Q8NHC4 |
| OMIM ID | 618456 |
| HGNC ID | 14791 |
| Aliases | OR2J3P, OR2J3Q, OR2J3R, OR2J3S |
Description
OR2J3 is a member of the olfactory receptor gene family, which are G protein-coupled receptors (GPCRs) responsible for detecting odorants in the nasal epithelium. These receptors are characterized by a seven-transmembrane domain structure and are involved in the initiation of the olfactory signal transduction cascade. OR2J3 is located on chromosome 6p22.1 and is expressed in olfactory mucosa and other tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs201430561 | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants
Gain of Function (GOF)
No documented gain-of-function variants
Dominant Negative (DN)
No documented dominant-negative variants
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • plasma membrane | • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR ligand binding (Reactome: R-HSA-375276)
Protein Summary
OR2J3 encodes a 312-amino acid olfactory receptor protein with a typical seven-transmembrane domain structure. It functions as a GPCR that binds odorant molecules and activates the olfactory signaling pathway via G protein activation. The protein is primarily localized to the plasma membrane of olfactory sensory neurons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR2J3 Knockout HEK293 Cell Line | EDJ-KQ8589 | Human | 442186 | Details Get a Quote |
| OR2J3 Knockout HeLa Cell Line | EDJ-KQ60447 | Human | 442186 | Details Get a Quote |
| OR2J3 Knockout A-549 Cell Line | EDJ-KQ68916 | Human | 442186 | Details Get a Quote |
| OR2J3 Knockout HCT 116 Cell Line | EDJ-KQ77277 | Human | 442186 | Details Get a Quote |
