OR1L3 Olfactory Receptor Family 1 Subfamily L Member 3
Olfactory receptor gene involved in odorant detection
Gene Information Card
| Symbol | OR1L3 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily L Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.2 |
| NCBI Gene ID | 26742 ncbi.nlm.nih.gov/gene/26742 |
| Ensembl ID | ENSG00000254772 |
| UniProt ID | Q8NH84 |
| OMIM ID | 618416 |
| HGNC ID | 8253 |
| Aliases | OR1L3P, OR1L3Q, OR1-25 |
Description
OR1L3 is a member of the olfactory receptor family, which are G protein-coupled receptors (GPCRs) responsible for detecting odorants. These receptors are expressed in the olfactory epithelium and mediate the sense of smell. OR1L3 is located on chromosome 9q33.2 and is classified as a protein-coding gene. Its specific ligand and physiological role remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 0.5 | Low |
| Testis | 0.2 | Low |
| Brain | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function variants
Gain of Function (GOF)
No known gain-of-function variants
Dominant Negative (DN)
No known dominant-negative variants
View complete mutation data：
Gene Ontology (GO)
Pathways
• Olfactory transduction (KEGG:04740)
• GPCR signaling (Reactome:R-HSA-372790)
Protein Summary
OR1L3 encodes a 312-amino acid olfactory receptor protein with seven transmembrane domains, characteristic of GPCRs. It is predicted to bind odorants and activate downstream signaling via G proteins. Expression is primarily in olfactory epithelium, but low levels in other tissues suggest possible ectopic functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1L3 Knockout HEK293 Cell Line | EDJ-KQ8602 | Human | 26735 | Details Get a Quote |
| OR1L3 Knockout HeLa Cell Line | EDJ-KQ55970 | Human | 26735 | Details Get a Quote |
| OR1L3 Knockout A-549 Cell Line | EDJ-KQ64457 | Human | 26735 | Details Get a Quote |
| OR1L3 Knockout HCT 116 Cell Line | EDJ-KQ72913 | Human | 26735 | Details Get a Quote |
