OR1G1 Olfactory Receptor Family 1 Subfamily G Member 1
A chemosensory GPCR involved in odorant detection and potential roles in extra-nasal tissues.
Gene Information Card
| Symbol | OR1G1 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily G Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 26742 ncbi.nlm.nih.gov/gene/26742 |
| Ensembl ID | ENSG00000184933 |
| UniProt ID | Q8NGA6 |
| OMIM ID | 618442 |
| HGNC ID | 8197 |
| Aliases | OR1G1P, OR17-130, OR1G1_17001 |
Description
OR1G1 is a member of the olfactory receptor (OR) family, which are G protein-coupled receptors (GPCRs) responsible for detecting odorants in the nasal epithelium. The gene is located on chromosome 17p13.3 and encodes a 312-amino acid protein. OR1G1 is known to respond to various volatile organic compounds and may also be expressed in non-olfactory tissues, suggesting potential roles in chemosensation beyond the nose.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM, ClinVar, or COSMIC as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected (nTPM from GTEx) |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No detectable expression |
| HeLa | 0.0 | No detectable expression |
| A549 | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Olfactory transduction (KEGG:04740)
• GPCR downstream signaling (Reactome:R-HSA-372790)
Protein Summary
OR1G1 is a 312-amino acid olfactory receptor with seven transmembrane domains, typical of class A GPCRs. It is involved in the detection of odorants and couples to G proteins to activate downstream signaling cascades. Structural studies indicate ligand-binding specificity for certain aliphatic and aromatic compounds. The protein is primarily localized to the plasma membrane of olfactory sensory neurons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1G1 Knockout HEK293 Cell Line | EDJ-KQ6224 | Human | 8390 | Details Get a Quote |
| OR1G1 Knockout HeLa Cell Line | EDJ-KQ54896 | Human | 8390 | Details Get a Quote |
| OR1G1 Knockout A-549 Cell Line | EDJ-KQ63383 | Human | 8390 | Details Get a Quote |
| OR1G1 Knockout HCT 116 Cell Line | EDJ-KQ71851 | Human | 8390 | Details Get a Quote |
